Registration Dossier
Registration Dossier
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EC number: 931-312-3 | CAS number: 53880-05-0
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
According to REACH Annex IX, 9.3.2, column 2 the bioaccumulation study does not need to be conducted if the substance has a low potential for bioaccumulation. Rapid hydrolysis of the substance makes approximation of equilibrium in the environment impossible resulting in a low potential for bioaccumulation. For the bioaccumulation potential of the hydrolysis products see the discussion below.
Key value for chemical safety assessment
Additional information
According to experience with the substance itself as well as with similar polyisocyanates, the amines formed in the initial hydrolysis step, which is associated with elimination of carbon dioxide, have a high reactivity towards unreacted isocyanate. The consequence is that in the hydrolysis of isophorone diisocyanate oligomer predominantly polyurea molecules are formed. They are insoluble in water and they cannot bioaccumulate due to the absence of sufficient mobility. Therefore not only the substance itself but also its hydrolysis products have a low potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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