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EC number: 201-280-9 | CAS number: 80-46-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A study (Seki et al. 2003) provides an estimated NOEC of 0.10 mg/L based on fertility/reproduction.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.1 mg/L
Additional information
Reliable (Klimisch 1 or 2) long-term toxicity studies with fish have been conducted for p-tert-amylphenol and are included in this dossier.
The long-term toxicity of p-tert-amylphenol to fish was investigated by Seki et al. (2003) (Klimisch 1). The fish, Medaka (Oryzias latipes), was exposed to the test chemical for two generations following methods similar to OECD 210. The flow-through test was initiated with eyed-eggs and hatchability and time to hatch was determined and no significant difference from the control was found for the F0 generation. Growth, fecundity and fertility of the F0 generation were also determined. For the F0 generation, the NOEC for growth, fecundity, and fertility was 0.402 mg/L, 0.931 mg/L and 0.100 mg/L, respectively. For the F1 generation, the NOEC for growth was 0.100 mg/L.
Panter et al. (2006) conducted a study (Klimisch 1) with p-tert-amylphenol. Embryos (24hr post fertilization) of fathead minnow (Pimephales promelas) were exposed to test substance in a flow-through system in measured concentrations of 0.056, 0.18 and 0.56 mg/L for 107 days post hatch following methods based on OECD 210. Although the focus of this study was to measure effects on the gonads, secondary sexual characteristics and vitellogenin, survival and growth were also assessed. The NOEC at 107 days post hatch, based on survival and growth were 0.56 and 0.56 mg/L. respectively. The lowest NOEC of 0.18 mg/L was based on gonadosomatic index and gonadal sex of fish.
Gimeno et al. (1998) conducted a study (Klimisch 3) with p-tert-amylphenol. Male larvae, 50 days post-hatch, of common carp (Cyprinus carpio), were exposed to test substance in an intermittent flow-through system in measured concentrations of 0.10, 0.32 and 1 mg/L for 110 days. Although the focus of this study was to measure effects on the reproductive tract development, secondary sexual characteristics and vitellogenin, growth was also assessed. The NOEC, based on growth was >0.256 mg/L. Although this study is deemed not reliable since it did not follow acceptable guidelines, it is presented here for weight of evidence support.
Reliable (Klimisch 1) long-term toxicity studies with fish have been conducted for p-tert-amylphenol and are included in this dossier. A study (Seki et al. 2003) provides an estimated NOEC of 0.10 mg/L based on fertility/reproduction. Consequently this value will be taken as the long-term toxicity in fish endpoint for p-tert-amylphenol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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