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Diss Factsheets
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EC number: 233-343-1 | CAS number: 10124-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- The influence of chain length on the metabolic fate of condensed phosphates
- Author:
- Gosselin RE, Megirian R
- Year:
- 1 955
- Bibliographic source:
- J Pharmacol Exp Ther. 115(4):402-7; PMID: 13272192
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The respective LD50 values are cited from another publication, namely: Gosselin RE, Tidball CS, Megirian R, Maynard EA, Downs WL, Hodge HC, Metabolic acidosis and hypocalcemia as toxic manifestations of polymeric phosphates, J Pharmacol Exp Ther. 1953 ;108(1):117-27.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Sodium metaphosphate
- EC Number:
- 233-343-1
- EC Name:
- Sodium metaphosphate
- Cas Number:
- 10124-56-8
- Molecular formula:
- H6O18P6.6Na
- IUPAC Name:
- Sodium metaphosphate
- Details on test material:
- - Name of test material (as cited in study report): hexametaphosphate; NaMP-6
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- single i.p. injections in rats weighing 200 to 300 grams.
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Statistics:
- All concentrations given were converted from grams phosphorus (as they were expressed in the article) to grams of the respective test compound.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 632.11 mg/kg bw
- Remarks on result:
- other: Calculated from the given value (59 mg P/kg bw) using the molecular masses of phosphorus (90.97 g/mol) and sodium hexametaphosphate (611.77 g/mol).
- Other findings:
- The main cause for the observed mortalities seems to be severe metabolic acidosis due to hydrolytic release of phosphate / phosphoric acid.
Applicant's summary and conclusion
- Conclusions:
- This article cites a LD50 (i.p. rat) for sodium hexametaphosphate of 632.11 mg/kg bw, as calculated from the given value (192 mg/kg bw) which is expressed as amount of phosphorus. The main cause for the observed mortalities seems to be severe metabolic acidosis due to hydrolytic release of phosphate / phosphoric acid.
- Executive summary:
This article gives information on the acute toxicity of sodium hexametaphosphate after single i.p. injection. The given value is based on an earlier publication of the same author (Gosselin RE, Tidball CS, Megirian R, Maynard EA, Downs WL, Hodge HC, Metabolic acidosis and hypocalcemia as toxic manifestations of polymeric phosphates, J Pharmacol Exp Ther. 1953 ;108(1):117-27) which can be assumed to give further details on the experimental procedure.
The cited value for the LD50 (i.p., rat) is 192 mg phosphorus per kg body weight which can be converted into 632.11 mg/kg bw sodium hexametaphosphate using their molecular masses of 30.97 and 611.77 mg/kg bw, respectively. The main cause for the observed mortalities seems to be severe metabolic acidosis due to hydrolytic release of phosphate / phosphoric acid.
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