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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

One study was well conducted and negative effects both with and without S9 were observed indicated that the test material did not cause point mutation in bacterial reverse mutation test according to OECD TG 471 and 472 (Thompson, 1997) .

The genotoxicity was investiaged by Durward in 1997 via chromosome aberration test in CHL cells in vitro and the results indicated that test material did not have clastogenic effects under the conditions of the study.

Moreover, the laboratory facilities which comply with OECD Principles of Good Laboratory Practice were utilized in order to ensure the consistency and reliability for the results.

These two studies were utilized as key studies in substance genetic toxicity evaluation due to their high adequation, reliablility and relevance to this element.

Overall, in genotoxicity studies, the test chemical was not mutagenic in bacteria, nor did it induce an increased incidence of chromosomal aberrations in Chinese hamster lung cells in vitro. In vivo tests were not provided.

Short description of key information:
In vitro:
Negative result in bacteria (Salmonella typhimurium and Escherichia coli) with and without metabolic activation (OECD TG 471)
Negative result in chromosomal aberrations (Chinese hamster lung cells)with and without metabolic activation.(OECD TG 472)

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

According to the existing studies in vitro tests which included bacterial reverse mutation test and mammalian chromosome aberration test (Chinese hamster lung cells ) were provided negative results displayed the BDP was not mutagenic in bacteria, nor did it induce an increased incidence of chromosomal aberrations. However, in vivo tests were not provided and further study should be considered.