Registration Dossier
Registration Dossier
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EC number: 200-898-6 | CAS number: 75-75-2
Biotransformation and kinetics
Administrative data
- Endpoint:
- biotransformation and kinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Molecular Analysis of a Novel Methanesulfonic Acid Monooxygenase from the Methylotroph Methylosulfonomonas methylovora
- Author:
- De Marco P, Moradas-Ferreira P, Higgins TP, McDonald I, Kenna EM, Murrell JC
- Year:
- 1 999
- Bibliographic source:
- Journal of Bacteriology 181, 7: 2244-2251
Materials and methods
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
Constituent 1
Results and discussion
Any other information on results incl. tables
Methanesulphonic acid is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Such as the facultative methylotroph bacterium Methylosulfonomonas methylovora, which was isolated from garden soil, or the bacterium Marinosulfonomonas methylotropha, which was isolated from the marine environment.
In a first step methanesulphonic acid gets oxidized to formaldehyde, which can then be either assimilated through the serin cycle or fully oxidized to yield CO2 and H2O in order to produce reduction power and energy for the cell. It was shown that the inducible enzyme responsible for the oxidation of methanesulphonic acid is a multicomponent monooxygenase. The multicomponent monooxygenase appears from its substrate specificity to be a unique oxygenase with a rather narrow substrate range. O2 consumption studies and cell extract assays demonstrated a restricted substrate range that includes only short-chain aliphatic sulfonates (methane- to butanesulfonate) and excludes all larger molecules.
Applicant's summary and conclusion
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