Registration Dossier
Registration Dossier
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EC number: 429-270-1 | CAS number: 136210-30-5
Endpoint summary
Administrative data
Description of key information
Additional information
The stability of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester towards hydrolysis was determined according to the OECD-guideline 111 (Bayer Industry Services, 2006). Based on kinetic parameters, the following dissipation half-lives for a temperature of 25 °C were extrapolated based on the Arrhenius equation:
pH 4 (25 °C): t1/2: 655 h
pH 7 (25 °C): t1/2: 25.4 h
pH 9 (25 °C): t 1/2: 16.8 h
Bis-aspartic-mono-acid triethylester, bis-aspartic-di-acid diethylester, bis-aspartic-tri-acid monoethylester and bis-aspartic-tetra-acid of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester
could be determined as hydrolysis products by the means of a HPLC-MS method.
Study was performed with aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester which is a structural analogue to aspartic acid, N,N'-(methylenedi-4,1-cyclohexanediyl)bis-, 1,1',4,4'-tetraethyl ester.Both substances are diethyl esters of aspartic acid linked to a dicyclohexylmethyldiamine moiety. The difference between these two substances is merely the presence of two methyl groups connected to the cyclohexane rings. This structural analogy was confirmed by the Member State responsible for the notification of both substances under the NONS regulation. The Member State decided that test results obtained for one substance can be transferred to the other substance and that testing of both substances is usually not required. This decision is in accordance with the grouping of substances and read-across approach in Annex XI, 1.5 of the REACH Regulation.
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