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EC number: 259-461-3 | CAS number: 55066-48-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1987-06-02 to 1987-06-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted in accordance with the standardised guidelines OECD 404 and EU Method B.4 and performed in line with GLP with a sufficient level of detail to assess the quality of the presented data. The study was performed on a similar substance to 3-methyl-5-phenylpentanol; the test substance in this study is the aldehyde of 3-methyl-5-phenylpentanol and as such is considered to be sufficient for read-across to address the endpoint.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 55066-49-4
- EC Number:
- 611-227-5
- Cas Number:
- 55066-49-4
- IUPAC Name:
- 55066-49-4
- Reference substance name:
- -
- EC Number:
- 433-900-0
- EC Name:
- -
- IUPAC Name:
- 433-900-0
- Reference substance name:
- 3-methyl-5-phenylpentan-1-al
- IUPAC Name:
- 3-methyl-5-phenylpentan-1-al
- Test material form:
- other: liquid (not specified)
- Details on test material:
- - Physical state: Liquid, clear, colourless
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ENKI-Konjnegarm, Someren, The Netherlands
- Weight at study initiation: 2500-3500 g
- Housing: Housed individually in suspended galvanized cages, fitted with wire-mesh floor and front
- Diet: standard laboratory diet ad libitum
- Water: tap water ad libitum
- Acclimation period: At least 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3 °C
- Humidity (%): at least 40 %
- Air changes (per hr): ca. 10 changes/hour
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied : 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Intact skin on the back and flanks under a 1 x 1 inch patch
- Type of wrap if used: The patches were fixed to the exposure site by adhesive tape and the entire trunk of each rabbit was wrapped with an impervious material.
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize et al (1944)
A. ERYTHEMA AND ESCHAR FORMATION
No erythema - 0
Very slight erythema (barely perceptible) - 1
Well-defined erythema - 2
Moderate to severe erythema - 3
Severe erythema (beet redness); eschar formation (injuries in depth) - 4
B. OEDEMA FORMATION
No oedema - 0
Very slight oedema (barely perceptible) - 1
Slight oedema (edges of area well-defined by definite raising) - 2
Moderate oedema (raised approximately 1 mm) - 3
Severe oedema (raised more than 1 mm, extending beyond the area of exposure) - 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritant / corrosive response data:
- The following effects were noted between 1 and 72 hours post patch removal:
Very slight, well-defined and moderate erythema; very slight or slight oedema; very slight ischemia; slight scaliness. During the course of the observation period, these effects cleared gradually. After 7 days, well-defined erythema and very slight oedema were observed. After 14 days, all irritation had cleared completely.
Any other information on results incl. tables
Table 1: Results
Animal No. |
Observation |
Hours after removal |
|||
1 |
24 |
48 |
72 |
||
4486 |
Erythema |
2 |
3 |
3 |
3 |
Oedema |
1 |
1 |
1 |
1 |
|
4487 |
Erythema |
4 |
2 |
1 |
1 |
Oedema |
1 |
1 |
1 |
1 |
|
4388 |
Erythema |
4 |
3 |
2 |
2 |
Oedema |
2 |
1 |
1 |
1 |
|
Average |
Erythema |
3.3 |
2.7 |
2.0 |
2.0 |
Oedema |
1.3 |
1.0 |
1.0 |
1.0 |
Erythema observations included ischemia, haemorrhages and incrustation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the test substance was found to be irritating, but not corrosive, to rabbit skin when applied undiltuted for four hours under occlusion.
- Executive summary:
The skin irritation and corrosion potential of the test substance was examined in vivo, in accordance with GLP and performed in line with the standardised guidelines OECD 404 and EU Method B.4. The study was performed on the aldehyde of 3-methyl-5-phenylpentanol, which is very similar both in structure and toxicological, ecotoxicological and physicochemical properties. The results of this study are therefore considered to be a good reflection of the properties of 3-methyl-5-phenylpentanol. Under the conditions of the test, irritation was noted in all animals which persisted past seven days. All effects were fully reversed by day 14. Under the conditions of the test, the test substance was found to be irritating, but not corrosive, to rabbit skin when applied undiluted for four hours under occlusion.
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