Registration Dossier
Registration Dossier
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EC number: 201-842-3 | CAS number: 88-60-8
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: non-validated system, few relevant details reported
Data source
Reference
- Title:
- Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen (TM) cells
- Author:
- Araki N, Ohno K, Nakai M, Takeyoshi M, Iida M|
- Year:
- 2 005
- Bibliographic source:
- Toxicology in vitro 19; 831-842 (2005)
Materials and methods
- Type of study / information:
- Androgen receptor binding - in vitro
- Principles of method if other than guideline:
- a pilot study was conducted to validate the use of AR-Eco-Screen (trademark) cells for tier 1 screening of androgen receptor (AR) agonist and antagonist activities. 253 compounds including 6-tert-butyl-m-cresol were tested
- GLP compliance:
- no
Test material
- Reference substance name:
- 6-tert-butyl-m-cresol
- EC Number:
- 201-842-3
- EC Name:
- 6-tert-butyl-m-cresol
- Cas Number:
- 88-60-8
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2-tert-butyl-5-methylphenol
- Details on test material:
- purity: 98.7%; purchased from Wako (Osaka, Japan)
Constituent 1
Results and discussion
Any other information on results incl. tables
6 -tert-butyl-m-cresol did not show androgenic nor anti-androgenic effects
Applicant's summary and conclusion
- Executive summary:
method: a pilot study was conducted to validate the use of AR-Eco-Screen (trademark) cells for tier 1 screening of androgen receptor (AR) agonist and antagonist activities. 253 compounds including 6-tert-butyl-m-cresol were tested
result: 6 -tert-butyl-m-cresol did not show androgenic nor anti-androgenic effects
reference: Araki, 2005
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