Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 416-250-2 | CAS number: 84632-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Read-across justification:
Data on terrestrial toxicity of the test substance are not available. However acute data on the toxicity to soil macroorganismen and data on the toxicity to terrestrial plants are available from 2 analogous substances. Both analogue substances (EC 465-080-5 and EC 401-540-3) are also DPP-pigments. All substances share the same common functional group, the 2,5-dihydro-pyrrolo(3,4-c)pyrrole-1,4-dione core. They only differ in the moiety. The analogue substance 1 is a reaction mass and has a chlorine moiety either in ortho-, meta- or para-position of both phenyl rings instead of a tert-butyl moiety. And analogue substance 2 has a chlorine moiety in para position of both phenyl. Effects on toxicity and behavior within the environmental compartments due to the different moieties are not expected.
All substances are not readily biodegradable and due to the inert structure no break-down products will occur in any environmental compartment. Additionally, all substances have a very low solubility in water and a similar molecular weight. Due to their similar PC properties the behavior within the environmental compartments is comparable. Additional, all substances show same results in the aquatic toxicity test and no toxic effects occur within the range of solubility for all trophic levels (acute and chronic). Additionally, the terrestrial studies on both analogue substances show also no effects up to a concentration of 1000 mg/kg test substance. Since the PC properties are almost the same and also all substances show no effects up to the solubility limit neither in acute nor in chronic studies it can be expected that the results of the terrestrial studies of the two analogues substances can be used as read-across. The same results are expected for the test substance. Therefore, in overall conclusion, the read-across is justified.
|
EC 416-250-2 (test substance) |
EC 465-080-5 (read-across substance 1) |
EC 401-540-3 (read-across substance 2) |
Structure (can be found in the CSR-pdf) |
|||
Physico-chemical data |
|||
Mol. weight |
400.521 |
357.2 |
357.196 |
Melting point |
>500°C |
>425°C |
> 300°C |
Relative density |
1.202 |
1.600 |
1.58 |
Water solubility (mg/L) |
< 0.1 |
< 0.5 |
< 0.499 |
LogKow |
5 |
4.5 - 4.7 |
< 3 |
Environmental fate data |
|
||
Hydrolysis |
Not expected, low water solubility |
Not expected, low water solubility |
Not expected, low water solubility |
Biodegradation in water |
No biodegradation observed |
No biodegradation observed |
No biodegradation observed |
Bioaccumulation (OECD 305) |
BMF =0.0151 BCF < 25 |
-- |
-- |
Adsorption/desorption (logKoc) |
6.639 (calculated) |
4.95 (HPLC) |
4.1 (calculated) |
Ecotoxicity data |
|
||
Short-term toxicity to fish (OECD 201) |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
Short-term toxicity to aquatic invertebrates (OECD 202) |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
Short-term toxicity to aquatic algae and cyanobacteria (OECD 201) |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
Long-term toxicity to fish (OECD 204) |
-- |
-- |
No chronic toxic effects within the range of solubility |
Long-term toxicity to aquatic invertebrates (OECD 211) |
No chronic toxic effects within the range of solubility |
No chronic toxic effects within the range of solubility |
No chronic toxic effects within the range of solubility |
Toxicity to micro-organisms (OECD 209) |
EC50 > 100 mg/L |
EC50 > 100 mg/L |
EC50 > 100 mg/L |
Toxicity to soil macroorganisms (OECD 207) |
-- |
LC50 > 1000 mg/kg |
LC50 > 1000 mg/kg |
Toxicity to terrestrial plants (OECD 208) |
-- |
-- |
LC50 (emergence) > 1000 mg/kg EC50 (growth) > 1000 mg/kg |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.