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EC number: 242-538-0 | CAS number: 18727-04-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Cobalt citrate
Oral: LD50 (rat) = 500 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 Feb 2012 - 07 Mar 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- adopted in 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Secrétariat général du GIPC - DGCIS, Services de l'industrie, bureau de la chimie, Paris, France
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Additional information on strain: SPF Caw
- Source: Elevage Janvier (53940 Le Genest St Isle, France)
- Age at study initiation: 8 weeks
- Fasting period before study: yes (food was removed on day 0 and then redistributed 4 hours post-application)
- Weight at study initiation: 196 - 212 g
- Housing: 3/cage in solid-bottomed clear polycarbonate cages with a stainless steel mesh lid
- Diet: pelleted M20 rat/mouse maintenance diet (Extralabo from Pietrement); ad libitum
- Water: tap water; ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30 - 70
- Air changes (per hr): approx. 15
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: step 1 and 2: 200 mg/mL; step 3 and 4: 30 mg/mL
- Amount of vehicle (if gavage): 10 mL
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- 2000 mg/kg bw (step 1 and 2)
300 mg/kg bw (step 3 and 4) - No. of animals per sex per dose:
- 3 per step (females)
- Control animals:
- other: no concurrent control; vehicle control tested approx. 2 months before
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: day 0, 2, 7, and 14
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The LD 50 cut-off value is considered to be 500 mg/kg bw according to the OECD guideline No. 423.
- Mortality:
- - 2000 mg/kg bw: 6/6 animals died
(step 1: 1/3 on day 3, 2/3 on day 5; step 2: 2/3 on day 3, 1/3 on day 4)
- 300 mg/kg bw: 0/6 animals died - Clinical signs:
- other: - 2000 mg/kg bw: decrease in spontaneous activity (6/6), decrease in muscle tone (1/6), decrease in righting reflex (1/6), and piloerection (4/6) (all signs from 48 hours post-treatment) - 300 mg/kg bw: No clinical signs related to the administeration of
- Gross pathology:
- - 2000 mg/kg bw: Due to marked signs of autolysis, the macroscopical examinations were not possible in 5/6 animals. Examination of one dead animal revealed an important thinning of the forestomach and a thinning of the corpus with black spots.
- 300 mg/kg bw: No treatment-related findings were observed. - Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: Acute Oral 4, H302
DSD: Xn, R22
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 500 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 1), and is thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, of Regulation (EC) No 1907/2006.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral toxicity study has been performed according to OECD 423 (Colas, 2012). 6 female rats each received a single oral dose of 2000 mg/kg bw or 300 mg/kg bw cobalt citrate. In the lower dosed group, all animals survived and no test substance-related clinical signs were observed. Macroscopical examination of the animals did not reveal treatment-related changes.
All 6 females treated with 2000 mg/kg bw died: 3 during the first step of the study on day 3 (1/3) and on day 5 (2/3), and 3 during the second step of the study on day 3 (2/3) and on day 4 (1/3). No clinical sign was noted during the first 24 h after the treatment. From 48 h post-dose, the mortatilites were preceded by decrease in spontaneous activity (6/6), in muscle tone (1/6), and in righting reflex (1/6), and piloerection (4/6). Rigor mortis and diarrhoea were noted before the necropsy (1/6). Due to the marked signs of autolysis, the macrosopical examinations were not possible in 5 animals (5/6). The The LD50 cut-off was determined to be 500 mg/kg bw cobalt citrate.
No experimental data are available for acute toxicity following inhalation and dermal contact.
Justification for selection of acute toxicity – oral endpoint
There is only one study available.
Justification for classification or non-classification
The available data on acute oral toxicity meet the criteria for classification as Category 4, H302 according to Regulation (EC) 1272/2008 and as Xn, R22 according to Directive 67/548/EEC.
No experimental data are available for acute toxicity via the inhalation and dermal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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