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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-699-2 | CAS number: 109-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: American Society for Testing and Materials (ASTM), Standard Test Method for Estimating Sensory Irritancy of Airborne Chemicals, Annual Book of ASTM Standards Designation E 981-84
- Principles of method if other than guideline:
- Comparative study including a series of primary, secondary and tertiary amines:
Determination of sensory irritation potency by oronasal exposure, key parameter: RD50
(RD50 = the exposure concentration resulting in a 50-% decrease in the respiratory rate). - GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Butylamine
- EC Number:
- 203-699-2
- EC Name:
- Butylamine
- Cas Number:
- 109-73-9
- Molecular formula:
- C4H11N
- IUPAC Name:
- butan-1-amine
- Test material form:
- liquid
- Details on test material:
- n-Butylamine [CAS No. 109-73-9], from Fluka, purity >99%
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): n-butylamine
- Substance type: organic
- Physical state: liquid
- Analytical purity: no data, "high purity"
Test animals
- Species:
- mouse
- Strain:
- other: OF-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Domaine des Oncins, Saint Germain sur l´Arbresle
- Age at study initiation:
- Weight at study initiation: 20 - 25 g
- Fasting period before study: unfasted
- Housing: 10
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 d
ENVIRONMENTAL CONDITIONS:
controlled, air-conditioned (no details)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- nose only exposure
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Adsorption of the test substance to silica gel followed by desorption under simultaneous derivat
isation (m-toluene derivatives). Direct analysis: reverse-phase HPLC. - Duration of treatment / exposure:
- 15-60 min
- Frequency of treatment:
- single exposure
Doses / concentrations
- Remarks:
- Several concentrations measured from 83 - 215 ppm
- No. of animals per sex per dose:
- 5-6
- Control animals:
- other: internal control = each test animal before exposure
- Details on study design:
- Before, during and after exposure respiratory rate was determined:
Observation period: 60 min exposure, measurement 1x/15 min, 30 min recovery
Results and discussion
- Details on results:
- Respiratory irritation, 15 min RD50: 0.26-0.34 mg/L air, 84.0-112.0 ppm (analytical)
Any other information on results incl. tables
The RD50 was found to be 112 ppm = 0.34 mg/L (Gagnaire et al. 1989).
84 ppm = 0.26 mg/L is stated by Gagnaire et al. 1993.
Note: Calculation based on MW = 73 and molar volume of 24 L (20 °C): 1 ml/m3 = 3.04 mg/m3.
Applicant's summary and conclusion
- Conclusions:
- In mice, n-butylamine is an acute sensory irritant when inhaled: effective exposure levels in mice = ~80 - 110 mL/m3 = ~240 - 340 mg/m3
that produce a 50% suppression of the respiration rate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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