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Diss Factsheets
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EC number: 269-923-6 | CAS number: 68391-04-8 This substance is identified by SDA Substance Name: C12-C18 alkyl dimethyl amine and SDA Reporting Number: 16-040-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Reference
- Reference Type:
- publication
- Title:
- A comparison of the elimination and biotransformation of dodecyldimethylamine oxide (DDAO) by rats, rabbits, and man
- Author:
- Turan T.S. and Gibson W.B.
- Year:
- 1 981
- Bibliographic source:
- Xenobiotica 11, 447-458
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Metabolism study in rats after oral application of test substance.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dodecyldimethylamine
- EC Number:
- 203-943-8
- EC Name:
- Dodecyldimethylamine
- Cas Number:
- 112-18-5
- Molecular formula:
- C14H31N
- IUPAC Name:
- N,N-dimethyldodecan-1-amine
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- C14
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 180 - 230 g (range for animals treated with either DDA (this study) or DDAO)
- Fasting period before study: overnight
- Housing: stainless stell cages
- Individual metabolism cages: yes
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- single exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
135 mg/kg
- No. of animals per sex per dose / concentration:
- one animal
- Control animals:
- no
- Positive control reference chemical:
- No
- Details on dosing and sampling:
- Metabolite studies:
- Urine was sampled from 0-24 h. Samples were used for identificatin of metabolites
Results and discussion
- Preliminary studies:
- no preliminary study
Main ADME results
- Type:
- metabolism
- Results:
- metabolite profile was the same as that of the 0-24 h urine from rats dosed with 14C-DDAO (100 mg/kg)
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The metabolite profile was the same as that of the 0-24 h urine from rats dosed with 14C-DDAO (100 mg/kg). One metabolie that was identifies is N,N-dimethyl-4-aminobutyric acid. No further information available.
Applicant's summary and conclusion
- Conclusions:
- No bioaccumulation potential based on study results.
Under the conditions of the test the metabolite profile was the same as that of the 0-24 h urine from rats dosed with 14C-DDAO (100 mg/kg). - Executive summary:
One rat was exposed to 135 mg/kg 14C-DDA orally by gavage. The metabolite profile was the same as that of the 0-24 h urine from rats dosed with 14C-DDAO (100 mg/kg).
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