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Diss Factsheets
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EC number: 221-375-9 | CAS number: 3081-14-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Read-across was performed using data from a similar paraphenylediamine 44PD (N-(1,4-dimethylpentyl)-N'-phenylbenzene-1,4-diamine) . A read-across justification using structural considerations, relevant PC-data (water solubility, logKow), fate data (biodegradation, logKoc) as well as ecotoxicological data is attached in IUCLID chapter 13.
In a read-across approach with 44PD (containing two sec. Butyl moieties instead of two 2,4-Dimethylpentyl moieties for 77PD), the substance was found to hydrolyse rapidly with half-lives of 1.5h (pH9), 5.3h (pH7) and 230h (pH4) at 20°C. The primary hydrolysis products are 44-QDI (oxidised form of 44PD with a quinone-diimine structure), 44PDOH (N-1,4 dimethylpentyl-p-phenol) and 1,4-dimethylpentylamine. Secondary hydrolysis products are p-hydroquinone and p-benzoquinone. The final hydrolysis product is 1-methyl-propylamine (sec-butylamine).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 5.3 h
- at the temperature of:
- 20 °C
Additional information
As no full OECD 111 hydrolysis test at pH4,7 and 9 is available for 77PD, read-across to 44PD is performed. 44PD (CAS 101 -96 -2) is also a member of the PD family. Instead of two heptyl groups as for 77PD, 44PD contains two sec. butyl groups. Due to the chemical similarity hydrolysis behaviour is expected to also occur in a similar way. Most information can be taken from the prolonged test (14days), performed at pH7 at 20°C. The parent substance disappears completely within 24 hours. Primary metabolites 44 -QDI and 44PD-OH were observed as intermediates from day 1 to 3. Finally, p-hydroquinone and p-benzoquinone are formed as secondary metabolites. The respective amine (in case of 77PD: 1,4 -dimethylpentylamine) was also detected. After 14 days, p-benzoquinone has been transformed to p-benzoquinone which finally represents about 30% of the original molar concentration of the parent substance.
These results are in accordance with supporting data from Monsanto (1986) where a half life of 3.4h was found. In this study, p-hydroquinone had disappeared after 5 days.
Further information about hydrolytical pathway and supporting information from other PPDs is given in the read-across justification document attached to IUCLID chapter 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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