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EC number: 909-125-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well conducted and documented study according to current guidelines under GLP. Original report only in german.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of N,N-dimethyldecan-1-amide and N,N-dimethyloctanamide
- EC Number:
- 909-125-3
- Molecular formula:
- C10H21NO and C12H25NO
- IUPAC Name:
- Reaction mass of N,N-dimethyldecan-1-amide and N,N-dimethyloctanamide
- Details on test material:
- Mixture of N,N-Dimethyloctanamide and N,N-Dimethyldecanamide
color/state: yellow liquid
boiling point: circa 250°C
density: 0.88 kg/l (25°C)
unsoulable in water
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht, Strain: Hoe: WISKf(SPF71)
- Age at study initiation: 7 weeks (male), 8 weeks (female)
- Weight at study initiation: 177g (male), 179g (female)
- Fasting period before study: 16h prior and 4h after dosing
- Housing:airconditioned room, housed in macrolon cages (Tpy 4) on wood chips in group of 5 animal
- Diet (e.g. ad libitum): Altromin 1324, ad libitum
- Water (e.g. ad libitum): Tap water from plastic bottles, ad libitum
- Acclimation period: no, as animals were received from own breeding
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3°C
- Humidity (%):50±20%
- Photoperiod (hrs dark / hrs light): 12h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame (seed) oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: adapted to 2000mg/kg bw
- Amount of total volume applied to animal (if gavage): 10ml/kg bw
- Concentration (w/v): 20%
MAXIMUM DOSE VOLUME APPLIED: 10ml/kg bw
DOSAGE PREPARATION (if unusual): The test item was mixed with sesame seed oil, homogenicity and stability in the vehicle was verified.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: due to the assumed low toxicity of the test item the highst dose was conducted as a limit test - Doses:
- 2000mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- one female died on application day
- Clinical signs:
- other: Unspecific symptoms, adverse effects on motion sequence, respiration and reflexes were observed. The animal showed also abdominal and letaral position, lid narrows, epiphora, reduced surface temperature and signs of stupor.
- Gross pathology:
- Necropsy of died animal shows liver colouring and lobular pattern and diffuse redness of the gastric mucosa. Necropsy of the survived animals reveals no macroscopic visible alteration.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- An LD50 above 2000mg/kg bodyweight can be concluded from the experiment.
- Executive summary:
To investigate the acute oral toxicity of Hoe S 4166 the test substance was applied via gavage to male and female wistar rats according to OECD 401 under GLP.
One female died in the 2000 mg/kg on application day. Additional to unspecific symptoms adverse effects on motion sequence, respiration and reflexes were observed. The animal showed also abdominal and letaral position, lid narrows, epiphora, reduced surface temperature and signs of stupor. On day 7 after application all surviving animals were free of symptoms. The body weight gain was not affected.
In result a Dosis letalis media (LD50) above 2000mg/kg bodyweight can be drawn from the experiment.
Necropsy of died animal shows liver colouring and lobular pattern and diffuse redness of the gastric mucosa. Necropsy of the survived animals reveals no macroscopic visible alteration.
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