Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-813-0 | CAS number: 110-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Piperidine
- EC Number:
- 203-813-0
- EC Name:
- Piperidine
- Cas Number:
- 110-89-4
- Molecular formula:
- C5H11N
- IUPAC Name:
- piperidine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: Piperidine
- Substanz-No.: 77/283
- Physical state: liquid, limpid
- Analytical purity: 99 %
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WIGA, Sulzfeld, Germany
- Mean weight at study initiation: 185 ± 15 g,
- Housing: 5 animals per cage
- Diet: Herilan, mouse/rat/hamster maintenance diet; H. Eggersmann KG, Rinteln, Germany, ad libitum
- Water: Fully demineralized water each workday ad libitum; on holidays tap water ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 5
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure system: Whole-body inhalation system (Groups of 5 animals are placed in wire cages which are located in a glass-steel inhalation chamber, V= 200 I.)
- Generator system: Continuous infusion pump UNITA I (B. Braun); Glass evaporator with thermostat (BASF).
By means of a continuous infusion pump, constant amounts of the test substance were supplied to an evaporator heated to 69°C .
The vapours that were formed were mixed with a flow of fresh air and passed into the inhalation chamber.
By means of an exhaust air system, the pressure ratios in the inhalation system were adjusted in such a way that there was a pressure slightly below
the atmospheric pressure (negative pressure). The inhalation mixture was offered to the animals for inhalation for 4 hours.
TEST ATMOSPHERE
- Brief description of analytical method used:
1. Equipment, chemicals and solutions: Gas chromatograph HP 5840 A
2. Sampling:
- Apparatus: two successive absorption vessels and downstream fritted flask
- Sorption solvent: xylene
- Sampling rate: 1 L
- Withdrawn amount: up to 10 L
- Sampling site: in the immediate vicinity of the noses of the animals
- Sampling probe diameter: 4 mm
3. Analytical test method: gas chromatography; piperidine was determined in xylene. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal concentration [mg/L]: Group 1: 17.1; group 2: 7.7; group 3: 10.2; group 4: 5.1; group 5: 1.7
Analytical concentration [mg/L]: Group 1: 7.54; group 2: 5.30; group 3: 4.10; group 4: 2.80; group 5: 1.00 - No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing was done before treatment, after 7 days, after 14 days.
Observations were several times on the day of exposure and at least once daily afterwards.
- Necropsy of survivors performed: yes, animals were killed by C02 and similarly all animals deceased before scheduled sacrifice were necropsied.
- Other examinations performed: clinical signs and mortality: daily - Statistics:
- The statistical evaluation of the study was carried out based on a probit analysis of DJ Finney (Finney, DJ; Probit Analysis 1971, pp 1-150.
Published by the Syndics of the Cambridge University Press, Bentley House, 200 Euston Road, London N.W. 1).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 4.8 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- Group 1:
males: 10 animals died (9 animals died within the day of exposure, 1 animal died within 5 days post exposure);
females: all animals (10) died within the day of exposure.
Group 2:
males: 6 animals died (3 animals died within the day of exposure, 1 on day 1, 4 and 5 after exposure, respectively);
females: 1 animal died (1 animal died on day 12 after exposure);
Group 3:
males: 3 animals died (1 animal died within the day of exposure, 1 on day 1 after exposure, and 1 on day 7 after exposure);
females: 7 animals died (1 animal died after day 1 of exposure, 1 on day 5, 6, 7, 11, respectively and 2 on day 8 after exposure);
Group 4:
males: no animal died;
females: 1 animal died (1 animal died on day 12 after exposure);
Group 5: no animal died. - Clinical signs:
- other: Dose group 1, 2 and 3: severe watery nasal discharge; severe red discharge of the eyes; eyelid closure; nose wiping; cornea opacity; dyspnoea; tremor; clonic and jumping convulsions; abdominal and lateral position (experimental group 1 and 2); squatting
- Body weight:
- Mean body weight and body weight change (in parentheses):
Group 1: day 0: males: 186 g; females: 177 g;
Group 2: day 0: males: 181 g; females: 179 g; day 7: males: 161 (-20) g; females: 155 (- 24) g; day 14: males: 187 (+ 6) g; females: 174 (- 5) g;
Group 3: day 0: males: 184 g; females: 187 g; day 7: males: 176 (- 8) g; females: 145 (- 42) g; day 14: males: 207 (+ 23) g; females: 169 (- 18) g;
Group 4: day 0: males: 181 g; females: 179 g; day 7: males: 191 (+ 10) g; females: 163 (- 16) g; day 14: males: 229 (+ 48) g; females: 178 (- 1) g;
Group 5: day 0: males: 175 g; females: 182 g; day 7: males: 223 (+ 48) g; females: 197 (+ 15) g; day 14: males: 257 (+ 82) g; females: 205 (+ 23) g;
Control: day 0: males: 188 g; females: 178 g; day 7: males: 223 (+ 35) g; females: 198 (+ 20) g; day 14: males: 264 (+ 76) g; females: 208 (+ 30) g.
Compared to the control group, body weight gain in the treatment groups 2, 3 and 4 was considerably reduced, whereas the body weight gain of the treatment group 5 for the males was slighly enhanced and for the females slightly reduced. - Gross pathology:
- Group 1: Heart: acute dilation of the atria, acute congestion hyperemia; lung: slight acute emphysema, weak pulmonary edema;
Group 2: Heart: acute dilation of the atria, acute congestion hyperemia; stomach/intestine bleedings; intestine, flatulence; pulmonary edema;
Group 3: Heart: acute dilation of the atria, acute congestion hyperemia; lung: slight acute emphysema, acute lobular pneumonia;
Group 4: no abnormalities detected; one animal haggard;
Group 5: no abnormalities detected.
In animals sacrificed at the end of the study no abnormalities were detected.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.