Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 941-174-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
No experimental data on aquatic bioaccumulation are available for MDIPA-Esterquat C16-18 and C18 unsatd. According to REACH regulation (Annex XI, 1.5), a study on aquatic bioaccumulation does not need to be conducted for the substance under investigation if data from structurally closely related material are available. A justification for read-across is attached in the target record.
Measured BCF data are available for the structurally related substance Dimethyldioctadecyl ammonium chloride (DODMAC). The registration substance differs from DODMAC by the ester linking groups between the alkyl chains and the headgroup (effectively the dimethyl ammonium group); details are given below in the justification for read-across.
Regarding the BCF of MDIPA-Esterquat C16-18 and C18 unsatd., the BCF is expected to be lower than that of DODMAC:
The chemical structure of MDIPA-Esterquat C16-18 and C18 unsatd. includes, in contrast to DODMAC, two polar ester moieties that lower BCF and which are susceptible to biodegradation and/or hydrolysis which also will result in a lower BCF of MDIPA-Esterquat C16-18 and C18 unsatd. DODMAC is poorly biodegradable and much more stable than MDIPA-Esterquat C16-18 and C18 unsatd. For DODMAC no abiotic degradation is to be expected, for biotic degradation in water the degradation rate is very low (1.4 x 10E-4/d) (EU 2002).
The BCF of DODMAC was determined in a study in which juvenile fish (Pimephales promelas) were exposed for 24 h under flow-through conditions, followed by a depuration period of 72 h. A BCF of 104 L/kg was calculated based on the uptake rate constant (k1) of 1.35 mg/g x h and the depuration rate constant (k2) of 0.013 mg/g x h.
The measured BCF values for similar substances (DODMAC, DHTDMAC=dihydrogenated tallow alkyl dimethyl ammonium chloride) are 12 -32 L/kg (BUA-Report 191, 1995) and 13 - 256 L/kg (EU RAR, 2002). The EU RAR (2002) concluded 'bioaccumulation is indicated, but is assumed that it is low under environmental conditions. A BCF of 13 L/kg is used in the risk assessment... '
This is further supported by a QSAR calculation that yielded a calculated BCF value for MDIPA-Esterquat C16-18 and C18 unsatd. of 70.8 L/kg (EPIWIN v3.20, BCFWIN v2.17). As this QSAR model does not include metabolism, it can be considered a conservative estimate of BCF.
The low bioavailability of the substance (due to rapid and strong sorption to negatively charged surfaces in the aquatic environment) in combination with the rapid (bio) degradation of the bioavailable fraction (mainly due to the hydrolysis of the ester bond), make high bioconcentration factors for MDIPA-Esterquat C16-18 and C18 unsatd. even more improbable.
For the target substance MDIPA-Esterquat C16-18 and C18 unsatd. a BCF of the same order of magnitude and not higher than DODMAC is to be expected. The above information is considered as sufficient to support the conclusion that the bioaccumulation potential of MDIPA-Esterquat C16-18 and C18 unsatd. is expected to be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.