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EC number: 203-047-7 | CAS number: 102-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological information
Endpoint summary
Currently viewing:
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Hackett-Fields 1 JULI 1988 to 10 AUG 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (EPA OTS 798.4100)
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4100 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- Bühler test with Guinea pigs was performed before the LLNA was set as preferred test method.
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Davidson's Mills Farm, South Brunswick, NJ
- Weight at study initiation: 332-449 g
- Housing: gang-caged
- Diet (ad libitum): Purina guinea pig pellets
- Water (ad libitum): tap water
- Acclimation period: 24 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.8-22.2 - Route:
- epicutaneous, semiocclusive
- Vehicle:
- other: 95% ethanol
- Concentration / amount:
- pre-test : 1, 2, 4, 6.25, 8, 25, 50%
induction: 4% (highest non irritating dose)
challenge: 4% - Route:
- epicutaneous, semiocclusive
- Vehicle:
- other: 95% ethanol
- Concentration / amount:
- pre-test : 1, 2, 4, 6.25, 8, 25, 50%
induction: 4% (highest non irritating dose)
challenge: 4% - No. of animals per dose:
- 15 (5 of them were naive controls)
- Details on study design:
- RANGE FINDING TESTS:
The maximum non-irritating concentration of 4 % was determined in a range-finding test (4 animals in two sets, application of the test substance to the clipped dorsal thoracolumbar region, 4 test sites per animal, 0.5 ml of 1, 2, 4, 6.25, 8, 25 and 50% dilutions of the test substance in 95% ethanol, 6 h of semiocclusive exposure and examination 24 h after initial application)
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 10
- Exposure period: 6 h each
- Test groups: 10 animals
- Control group: 5 naive control animals per group
- Site: clipped dorsal thoracolumbar region
- Duration: 3.5 weeks
- Concentrations: 4%
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: 14 days after 10th induction application
- Exposure period: 6 h (not stated in study report, but according to guideline)
- Test groups: 10 animals
- Control group: 5 naive control animals per group
- Site: untreated site on left flank
- Concentrations: 4%
- Evaluation (hr after challenge): 24 and 48 h after challenge
- Challenge controls:
- 5 naive controls per group
- Positive control substance(s):
- yes
- Remarks:
- 0.08% dinitrochlorobenzene (DNCB) in 95% ethanol
- Positive control results:
- 6/10 test sites were erythematous 24 h after challenge, 4/10 were clear. At the 48 h reading there were 8 sites with erythema and 2 without effect. Scores ranged from 0.5 (very faint, nonconfluent) to 3 (strong).
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 4%
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 4%. No with. + reactions: 2.0. Total no. in groups: 10.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 4%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 4%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 5.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 5.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Dose level:
- 0.08% DNCB
- No. with + reactions:
- 6
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: positive control. Dose level: 0.08% DNCB. No with. + reactions: 6.0. Total no. in groups: 10.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- positive control
- Dose level:
- 0.08% DNCB
- No. with + reactions:
- 8
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: positive control. Dose level: 0.08% DNCB. No with. + reactions: 8.0. Total no. in groups: 10.0.
Reference