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Diss Factsheets
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EC number: 231-626-4 | CAS number: 7659-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: This study was performed according to generally accepted scientific standards, but it suffers severe limitations.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Repeated dermal application of substance on rat skin for 10 days.
Only one very low concentration was tested.
No data on environmental conditions.
The parameters examined were limited and results were not detailed. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl mercaptoacetate
- EC Number:
- 231-626-4
- EC Name:
- 2-ethylhexyl mercaptoacetate
- Cas Number:
- 7659-86-1
- Molecular formula:
- C10H20O2S
- IUPAC Name:
- 2-ethylhexyl 2-sulfanylacetate
- Details on test material:
- - Name of test material (as cited in study report): Thioglykolsäure-2-äthylhexylester
- Analytical purity: technical quality
- Impurities (identity and concentrations): no relevant impurity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: conventional random strain of the "Staatlichen Zentralstelle für versuchstierzucht und-versorgung, Berlin-Lichtenberg
- Sex:
- female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- ethanol
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- 5 day/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 mL/kg of a 20% solution in ethanol
Basis:
nominal per unit body weight
- No. of animals per sex per dose:
- 10 animal (including both sexes)
- Control animals:
- yes
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No local reaction was observed. Body weight gain was not affected in the animals, but 3 of
the 10 rats died on day 11. At the end of exposure period, necropsy was performed on surviving animals. No macroscopically visible
damage to the organs was evidenced. Results of mortality for control group were not reported.
Applicant's summary and conclusion
- Conclusions:
- In this study, animals were exposed dermally for 10 days to the substance applied in 20% solution in ethanol at 3 mL/kg, corresponding approximately to 0.58 mg/kg bw. No significant treatment-related effects were observed on bodyweight gain, or on organs macroscopically examined at necropsy, but 3/10 rats died on day 11.
- Executive summary:
- To study the subacute dermal toxicity of thioglycolic acid
2-ethylhexyl ester, 3 ml of a 20% ethanolic solution/kg body
weight (correponding approximately to 0.58 mg/kg) was applied to the clipped dorsal skin of 10 female
rats as a single dose daily for 2 weeks (10 exposures).No local reaction was observed. Body weight gain was not affected in the animals, but 3 of
the 10 rats died on day 11.At the end of exposure period, necropsy was performed on surviving animals. No macroscopically visible
damage to the organs was evidenced.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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