Registration Dossier
Registration Dossier
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EC number: 200-658-0 | CAS number: 67-52-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD 107
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Barbituric acid
- EC Number:
- 200-658-0
- EC Name:
- Barbituric acid
- Cas Number:
- 67-52-7
- Molecular formula:
- C4H4N2O3
- IUPAC Name:
- pyrimidine-2,4,6(1H,3H,5H)-trione
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- -2.39
- Temp.:
- 23 °C
- pH:
- ca. 3.2
- Remarks on result:
- other: mean of 6 measurements
Any other information on results incl. tables
Table 1: Results
no. |
stock solution [mL] |
n-octanol [mL] |
conc. in n-octanol phase [mg/L] |
conc. in water phase [mg/L] |
log pow |
A1 |
5 |
10 |
3.7 |
1023.4 |
- 2.44 |
A2 |
5 |
10 |
3.9 |
1022.0 |
- 2.42 |
B1 |
10 |
10 |
3.8 |
1044.4 |
- 2.44 |
B2 |
10 |
10 |
4.8 |
1035.1 |
- 2.34 |
C1 |
20 |
10 |
4.6 |
1048.3 |
- 2.36 |
C2 |
20 |
10 |
5.0 |
1058.0 |
- 2.32 |
mean |
- |
- |
- |
- |
- 2.39 |
Stock solution: 986 mg/L
The recovery rate of the test substance was between 104 % and 108 %.
Applicant's summary and conclusion
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