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EC number: 204-623-0 | CAS number: 123-38-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Bushy Run Research Center
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Propionaldehyde
- EC Number:
- 204-623-0
- EC Name:
- Propionaldehyde
- Cas Number:
- 123-38-6
- Molecular formula:
- C3H6O
- IUPAC Name:
- propanal
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): propionaldehyde
- Physical state: liquid
- Analytical purity: approx. 99.77%
- Impurities (identity and concentrations): n-propanol: 0.01%, 2-methyl butyraldehyde: 0.02%, valeraldehyde: 0.06%, propionic acid: 0.07%, propionaldehyde dimers: 0.03%, propionaldehyde trimers: 0.01%, all other: approx. 0.03%
- Storage condition of test material: room temperature
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Products, Inc. (Denver, PA, USA)
- Age at study initiation: 12 - 18 weeks old
- Weight at study initiation: 2.0 - 2.3 kg
- Fasting period before study: during acclimation: diet restricted during the first week
- Housing: individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16.1 - 21.7
- Humidity (%): 40-60
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal trunk
- % coverage: no data
- Type of wrap if used: double layer of gauze sheeting was wrapped around the trunk and secured with adhesive tape. Polyethylene sheeting was then wrapped around the trunk over the gauze. To secure the polyethylene, plastic ties or rubber bands were added (at the ends of the trunk). The sheeting was protected from removal or tearing by wrapping the rabbit trunk with VETRAP® badaging tape. The ends of the VETRAP® were then secured.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 6 mg/cm2 /(1.0 g/kg) for female; 49mg/cm2 (8.0 g/kg) for male
- Concentration (if solution): undiluted
- Constant volume or concentration used: yes
- Duration of exposure:
- 24 hours
- Doses:
- 1000, 2000, 4000 mg/kg b.w.
- No. of animals per sex per dose:
- 5 female per dose
3 male per 2000mg/kg bw. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: examination and weighing twice prior dosing; after dosing: once daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 460 mg/kg bw
- 95% CL:
- 1 790 - 3 390
- Mortality:
- 1 male rabbit died from 8.0 g/kg. One of 3 male rabbits died after receiving 2.0 g/kg of test substance (an intermediate dose level that produced 1 of 5 female deaths). After receiving of 4.0 g/kg of propionaldehyde 5/5 female rabbits died.
Three female rabbits died within 45 minutes to 1.75 hours. All other deaths occurred at 1 to 2 days. - Clinical signs:
- other: Dermal reactions included erythema, edema, ecchymosis, fissuring, necrosis, ulceration, desquamation, alopecia and scabs. Signs of toxicity included sluggishness, convulsion followed by spasms (in 1), prostration, labored breathing (in 1), rapid breathing
- Gross pathology:
- Necropsy of the rabbits that died revealed pale pink to red lungs (mottled in 1), 2 purple thymuses (mottled in 1) and 1 enlarged thymus. Gross pathologic evaluation of survivors revealed dark red lungs (in 1) and a white liquid-filled nodule in 1 kidney.
Any other information on results incl. tables
mean weight, (g ± S.D.) | |||||
Dose (g/kg b.w.) | Dead/dosed | days to death | 0 days | 7 days | 14 days |
Males | |||||
2.0 | 1/3 | 2 | 2648 ± 53 | 2574 ± 45 | 2697 ± 14 |
Female | |||||
4.0 | 5/5 | 0,0,1,1,2 | 2697 ± 129 | - | - |
2.0 | 1/5 | 0 | 2720 ± 91 | 2724 ± 86 | 2814 ± 119 |
1.0 | 0/5 | - | 2640 ± 199 | 2738 ± 168 | 2933 ± 203 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The median lethal dose after dermal application was concluded to be 2460 mg/kg b.w. for female New Zealand white rabbits under the conditions of the study. A marked gender difference was not observed.
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