Isopropyl acetoacetate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2010-09-07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

27.07.1995

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

45 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

250 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

>= 3.8 - <= 5.2

Preliminary Test:

mL of water for 0.1 g soluble	0.1	0.5	1	2	10	100	150
Approx. solubility in g/L	> 1000	1000 to 200	200 to 100	100 to 50	50 to 10	10 to 1	< 1
Visual evaluation	not soluble	not soluble	not soluble	not soluble	soluble	soluble	soluble

 

 

Flask method:

Three flasks containing approx. 250 g/L test substance in water were stirred for 5 h at 30 °C. Subsequently the flasks were stirred at 20 °C for 1 day, 2 days and 3 days respectively. After each day the content of one flask was centrifuged at 4000 rpm for 20 min. Subsequently the aqueous phase was filtered through a membrane filter (0.2 µm). The content of the test substance in the filtrate was determined by gas chromatography.

 

Flask No.	Equilibration time at 20 °C [h]	pH of aqueous solution	Test substance content [g/L]
1	24	5.2	45.4
2	48	3.8	44.8
3	72	3.8	45.2
mean	---	---	45.2

Conclusions:

The water solubility of the test item was found to be 45 g/L at 20 °C.

Executive summary:

A study was conducted according to OECD Guideline 105 (1995). In the preliminary test, the water solubility of the test item was determined to be approximately 10 to 50 g/L. Therefore, the flask method was performed. The mean concentration in the three flasks was 45.2 g/L. The water solubility of the test item was found to be 45 g/L at 20 °C.

Description of key information

The water solubility of the test item was found to be 45 g/L at 20 °C (reference 4.8-1).

Key value for chemical safety assessment

Water solubility:

45 g/L

at the temperature of:

20 °C

Additional information

A study was conducted according to OECD Guideline 105 (1995). In the preliminary test, the water solubility of the test item was determined to be approximately 10 to 50 g/L. Therefore, the flask method was performed. The mean concentration in the three flasks was 45.2 g/L. The water solubility of the test item was found to be 45 g/L at 20 °C.