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Diss Factsheets
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EC number: 204-101-2 | CAS number: 115-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- before 12 Apr 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- simple distillation and alternate method (reducing the heat history and blanketing the substance with nitrogen)
- GLP compliance:
- no
- Type of method:
- distillation method
- Boiling pt.:
- >= 259 - <= 260 °C
- Atm. press.:
- ca. 1 013 hPa
- Decomposition:
- yes
- Conclusions:
- The AEPD (2-amino-2-ethyl-1,3-propanediol) standard was prepared and then characterized by GC, GC/MS (EI and CI), NMR (1H and 13C), IR and titration determination that confirmed the assigned structure. This high purity material (99.5+%) was subsequently used to determine its boiling point as 259-260 °C at atmospheric pressure by two different methods.
Reference
The determination of the AEPD's boiling point by simple distillation:
Fraction No. |
Temp. range, °C |
Weight obtained, g |
Comment |
GC Analysis (% AEPD) |
1 |
RT-250 |
0.5 |
2 phases |
8.5 |
2 |
250-259 |
1.0 |
yellow oil |
80 |
3 |
259-260 |
2.0 |
yellow oil |
94 |
4 |
>260 |
0.5 |
yellow oil |
98.9 |
The majority of the substance distilled overhead in Fraction 3 (259-260 °C) even though some decomposition occurred at these elevated temperatures while open to the atmosphere. The purity dropped to 94.4 area% in the main fraction collected. Thus it appeared possible that this measured bp was lower than the actual value.
The results of the boiling point determination of AEPD at atmospheric pressure:
Measure No. |
Method used |
Boiling point, °C |
Device used |
AEPD purity, area% |
1 |
Distillation (method 1) |
259-260 |
Thermometer #1 |
94.4 |
2 |
Boiling point (method 2) |
259.0 |
Thermometer #2 |
99.8 |
3 |
Boiling point (method 2) |
260.0 |
Thermometer #3 |
~99 |
4 |
Boiling point (method 2) |
253.5 |
Thermometer #4 |
~97 |
5 |
Boiling point (method 2) |
262.2 |
J Thermocouple |
~96 |
6 |
Boiling point (method 2) |
256.5 |
Thermometer #5 |
~95 |
7 |
Boiling point (method 2) |
258.0 |
Thermometer #3 |
93.2 |
Heating the substance to its boiling point at atmospheric pressure had caused decomposition to occur. While this was most apparent when performing the simple distillation using a short path distillation system to take the AEPD overhead, the alternate method also resulted in decomposition even thought it was run under nitrogen and had a shorter heat history. Obviously this decomposition affects the reported bp as measurement #3 and #7 used the same thermometer / set-up; yet the bp for measurement #3 (99.5 area%) was 2.0 °C more than measurement #7 (93.2 area%) that had been heated for about an hour under nitrogen. Therefore adding 2.0 °C to run #7 and then throwing the low and the high bp values out, a value of 259 °C is reached as the boiling point of the AEPD. This matches the simple distillation value previously obtained.
Description of key information
259-260 °C at ambient pressure
Key value for chemical safety assessment
- Boiling point at 101 325 Pa:
- 259 °C
Additional information
Distillation method. Decomposition occurs. Under reduced pressure of 10 mmHg, 152 -153 °C reported (handbook data).
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