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EC number: 234-521-1 | CAS number: 12007-89-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of single and repeated exposure to biocidal active substances on the barrier function of the skin in vitro.
- Author:
- Buist HE, van de Sandt JJM, van Burgsteden JA & de Heer C
- Year:
- 2 005
- Bibliographic source:
- Regulatory Toxicology and Pharmacology 43: 76 – 84.
Materials and methods
- Type of study / information:
- The influence of repeated and single exposure to boric acid on the skin barrier was investigated in vitro using static diffusion cells from cryopreserved human abdominal skin from 7 female donors.
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The influence of repeated and single exposure to boric acid on the skin barrier was investigated in vitro using static diffusion cells from cryopreserved human abdominal skin from 7 female donors. The dermis was partially removed using forceps and scissors and the average skin thickness was 0.702 ± 0.062 mm. The skin preparations were exposed to 10 μL/cm2 of a solution of boric acid for 4 h (single exposure) starting 4 h after the onset of the experiment or for 3 times 4 h (repeated exposure, starting at 0, 24 and 48 h respectively). The test material was tested at 3 concentrations, representing the range of concentration in which it may be present in products. Each exposure period was finished by washing off the test substance using 4 cotton swabs humidified with 3 % Teepol solution and subsequently drying the skin preparations using 2 dry cotton swabs. The same procedure was applied ot the control skin. All skins were washed three times in order to control fora a possible effect of the washing procedure on skin permeability. For each concentration the single and multiple dosing experiments were always performed with skin from the same donor wiht controls performed in parallel. The integrity of the skin preparations were assessed prior to the start of the experiment by determining the permeability coefficient (Kp) of tritiated water. In addition [14C]propoxur was used as a marker of skin permeability by applying at the end of the exposure period. During the following 3 h samples of receptor fluid were collected for every hour and assayed for tritated water and 14C-radioactivity by liquid scintillation counting. Fluid was replaced by adding fresh receptor fluid after each sampling and the amound of radiolabelled marker molecules that had penetrated the skin was plotted against time.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- Molecular formula:
- H3BO3
- IUPAC Name:
- Boric acid
- Details on test material:
- - Name of test material: Boric acid
- Analytical purity: > 99 %
Constituent 1
Results and discussion
Any other information on results incl. tables
No clear and constant effect was noted on skin barrier function following boric acid application.
Applicant's summary and conclusion
- Conclusions:
- The influence of repeated and single exposure to boric acid on the skin barrier was investigated in vitro using static diffusion cells from cryopreserved human abdominal skin from 7 female donors. No clear and constant effect was noted on skin barrier function following boric acid application.
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