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EC number: 271-078-3 | CAS number: 68515-37-7 A complex combination of hydrocarbons produced by the esterification of phthalic anhydride with isononyl alcohol. It consists predominantly of C9 primary alcohols, C9 paraffins, and saturated and unsaturated C18 ethers and boiling in the range of approximately 120°C to 220°C (248°F to 428°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline (405): GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction
- EC Number:
- 308-482-7
- EC Name:
- Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction
- Cas Number:
- 98072-31-2
- IUPAC Name:
- 98072-31-2
- Details on test material:
- - Name of test material (as cited in study report): MRD-85-608
- Physical state: liquid
- Analytical purity: assumed 100 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): neat (assumed 100%) - Duration of treatment / exposure:
- Single instillation
- Observation period (in vivo):
- Observations at 1, 4, 24, 48, and 72 hours post-instillation and once per day on days 4 and 7.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: Driaze
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0.83
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Effects were fully reversible within 4 days in all but one animal
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0.83
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Effects were fully reversible within 4 days in all but one animal
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.5
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Effects were fully reversible within 4 days in all but one animal
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CAS# 98072-31-2 was found to be slightly irritating to the eyes. Effects were reversible within 4 days.
- Executive summary:
Discard alcohol (CAS #84852-02-8) is a mixture of components: a mixture of C8-13 branched hydrocarbons, C9-13 branched primary alcohols and C10-12 cyclic ethers. All components are multi-isomeric. The composition is variable. All structures are branched and multi-isomeric. For the purposes of read across, data from an equivalent alcohol will be used (isodecanol, CAS #68526-85-2), as will data from a commercial substance (Vammar D10, CAS #98072-31-2) that contains similar aliphatic ethers to discard alcohol.
Skin
As assessed in dermal irritation studies, CAS # 98072 -31 -2 is transiently irritating to the skin. In a study utilizing an occluded patch exposure, the presence of erythema was noted within 4 hours of patch removal and remained present until at least seven days post exposure. The severity of the erythema induced by CAS # 98072 -31 -2 exposure ranged from very slight to severe during this time frame. However, upon removal, signs of irritation subside. CAS # 98072 -31 -2 is also transiently irritating to the eye as assessed in rabbits. Redness was noted in all animals up to 24h post exposure and decreased steadily through 14 days post exposure.
CAS #68526-85-2 was administered via an occluded patch to 6 rabbits at a dose of 0.5 ml for 4 hours of exposure to assess dermal irritation. Observations were conducted at 45 minutes, 24, 48 and 72 hours and 7 days after exposure. Well defined erythema was noted in 1 animal at the 45 minute point while the other animals had very slight erythema. Erythema increased after the 45 minute interval. Five animals were noted with well-defined erythema at the 24 and 48 hour intervals; the mean primary dermal irritation index was 2.16. At the 72 hour interval, all animals were noted with well-defined erythema. Erythema increased again at the Day 7 interval; two animals were noted with severe erythema and four animals were noted with well-defined erythema. The mean skin irritation scores between 24 and 72 hours were: erythema 1.5 and edema 0.56.
Eye
The ocular irritation potential of CAS# 98072-31-2 was evaluated following a single 0.1 ml instillation to the right eye of 6 rabbits. The treated eyes of all animals remained unwashed. Observations for signs of ocular irritation and toxicity were made at 1, 4, 24, 48, and 72 hours post-instillation and once per day on days 4 and 7. Ocular reactions were graded according to the Draize scale for scoring ocular lesions. Minimal irritation was observed in the animals; responses were limited to the conjunctiva and included redness, chemosis and discharge. All effects were fully reversible within 7 days post-instillation. In all but one animal, all effects were fully reversed within 4 days post-instillation.
CAS #68526-85-2 was evaluated for acute eye irritation by a single instillation of 0.1 ml into the left eye of 6 rabbits. Slight to moderate eye irritation was observed within 1 h post instillation and included slight corneal opacity, slight iritis, and slight to moderate conjunctival redness. All signs of irritation were resolved by Day 7 post exposure. Mean eye irritation scores between 24 and 72 hours were: cornea score 0.5, iris score 0.5, and conjunctival redness 1.54.
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