Registration Dossier
Registration Dossier
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EC number: 222-619-7 | CAS number: 3558-60-9
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 38 days to 5.0 yrs, at pH range 7-8 and a temperature of 25°C.
Additional information
Hydrolysis:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:
The base catalyzed second order hydrolysis rate constant and half-life value of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant was determined to be 0.04 L/mol-sec with a corresponding half-life of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
In an another study, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec.The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 38 days to 5.0 yrs, at pH range 7-8 and a temperature of 25°C. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
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