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EC number: 622-542-2 | CAS number: 3891-98-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8/18/10 - 11/29/10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2,6,10-trimethyldodecane
- EC Number:
- 622-542-2
- Cas Number:
- 3891-98-3
- Molecular formula:
- C15H32
- IUPAC Name:
- 2,6,10-trimethyldodecane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Farnesane
- CAS number: 3891-98-3
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals, Boyertown, PA on 08/03/10 & Taconic Farms, Hudson, NY
- Age at study initiation: The animals were born the week of 06/08/10 and on 06/21/10. First exposure to test subtance was on 8/31/10
- Weight at study initiation: 224 - 259 grams. The weight variation of the animals used did not exceed + 20% of the mean weight of the previously dosed animals. See body weight data summarzied in "administration/exposure" section.
- Housing/Environmental conditions: The animals were identified by cage notation and indelible body marks, and individually housed in suspended stainless steel wire bottom cages. Paper bedding was placed beneath the cages and changed at least three times per week. The animal room, reserved exclusively for rats on acute tests, was temperature controlled, had a 12 hour light/dark cycle, and was kept clean and vermin free.
- Diet (e.g. ad libitum): Fresh PMI Rat Chow (Diet #5012) was freely available except for 16-20 hours prior to dosing.
- Water (e.g. ad libitum): Available ad libitum
IN-LIFE DATES: From: 8/31/10 To: 9/22/10
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Initially, one rat dosed at 5000 mg/kg. Since the animal survived, two additional animals were dosed at 5000 mg/kg. The rats were observed at 15 minutes, 1, 2 and 4 hours post dose and once daily for 14 days for toxicity and pharmacological effects. All animals were observed twice daily for mortality.
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- -Oral dosing by syringe and dosing needle
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily for mortality; twice daily for toxicity and pharmacoligical effects; weighed pre-test, once weekly, and at termination.
- Necropsy of survivors performed: yes - Statistics:
- Animal # Dose volume (cc) Body Weight (g) Day 0 Body Weight (g) Day 7 Body Weight (g) Day 14
1 1.7 259 295 295
2 1.5 224 267 253
3 1.5 227 250 252
Mean 237 271 267
Std. Dev 19.4 22.7 24.5
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/3
- Clinical signs:
- other: -A single instance of anogenital area wetness was noted during the observation period. See "Adminstration/Exposure" for summary table.
- Gross pathology:
- Normal
- Other findings:
- No
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Oral LD50 > 5000 mg/Kg
- Executive summary:
Initially, one healthy feamle Sprague Dawley rat was dosed orally with farnesane at 5000 mg/kg. Since the animal survived, two additional animals were dosed at 5000 mg/Kg. The rats were observed at 15 minutes, 1, 2, and 4 hours post-dose and once daily for 14 days for toxicity and pharmacological effects. All animals were oberved twice daily for mortality. Body weights were recorded immediately pre-test, weekly, and at termination. All animals were examined for gross pathology. The potential for toxicity was based on the mortality response noted. All animals survived the 5000 mg/kg oral dose. A single instance of wetness of the anogenial rae was noted during the observation period. Body weight changes wer normal in 2/3 animals. one animal lost weight within the last week of observations. Necropsy results were normal.
Conclusion: The LD50 of farnesane is greater than 5000 mg/Kg body weight in female rats.
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