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Diss Factsheets
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EC number: 220-150-2 | CAS number: 2643-07-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a Murine Local Lymph Node Assay according to OECD Guideline 429 in compliance with GLP N-Chloroethyl,N-Ethyl-4-Aminobenzaldehyd showed a skin sensitising effect (BASF SE, 2010).
No signs of systemic toxicity were noticed. When applied as 0.3% and 1% preparations in MEK, the test substance induced a response (increase to 1.5-fold or above of control value = stimulation index (SI)≥1.5) in the auricular lymph node cell counts at the border of biological relevance. In addition there was a slight increase in lymph node weights. The increase of 3H-thymidine incorporation into the cells was biologically relevant (increase above the cut off stimulation index of 3) at the concentration of 1%. The 0.3% test-substance preparation caused an increase of 3H-thymidine incorporation into the cells, which failed the cut off stimulation index of 3 and thus lies below the threshold of immunologic relevance. The increase in 3H-thymidine incorporation was concentration dependent. The 1% test-substance preparation caused some increase in ear weights as a sign of minimal ear skin irritation. Due to the biological relevant increases in lymph node cell counts and concentrationresponse relationship in 3H-thymidine incorporation without the presence of distinct ear skin reaction, the results indicate that a skin sensitization potential of the test substance cannot be excluded. Thus it is concluded that N-Chloroethyl,N-Ethyl-4-Aminobenzaldehyd shows a skin sensitising effect in the Murine Local Lymph Node Assay under the test conditions chosen.
The threshold concentration for sensitization induction was > 0.1% < 1% (> 0.1% < 0.3% for the cell count SIs; slightly below 1% for the 3H-thymidine incorporation SIs). The estimated concentration that leads to the SI of 1.5 for cell count (EC 1.5) and the estimated concentration that leads to the SI of 3.0 for3H-thymidine incorporation (EC 3) were calculated by linear regression from the results of the 0.1% and 0.3% concentrations (cell count SIs) or of the 0.3% and 1% concentrations (3H-thymidine incorporation SIs) to be 0.3% or 0.8%, respectively.
Migrated from Short description of key information:
LLNA (mouse): Sensitising to the skin (EC 1.5 approx. 0.3%, EC 3 approx. 0.8%)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
There are no data available concerning respiratory sensitisation.
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- Sensitising to the skin, R43
GHS classification according to 2nd ATP to 1272/2008 CLP (EU GHS):
- Skin sensitisation Category 1A
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