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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur

Description of key information

The short term toxicity to fish is waived as the substance is highly insoluble in water. A supporting non-GLP study on fish embryo toxicity was performed in a GLP lab in a similar set up as OECD 236. The NOELR was 10 mg/L and the EL50 >= 10 mg/L, which is far above the water solubility of the substance.

Key value for chemical safety assessment

Additional information

The substance is highly insoluble in water and hence, it is not needed to perform short term toxicity to fish. However, the short term toxicity of 2,5-dimethyl-2,5-di(2-ethylhexanoylperoxy)hexane to fish embryo was tested with a non-GLP screening study conducted similar to OECD 236. The study was conducted without chemical analysis and with less replicates and concentrations compared to a strict OECD 236 guideline test. Also, less physical chemical measurements were taken. Water accommodated fraction was used as it is recommended for poorly soluble and instable substances. Hence, results are based on nominal loading rates of the WAF. The NOELR was 10 mg/L and the EL50 >= 10 mg/L, far above the water solubility of the substance.