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EC number: 407-870-4 | CAS number: 97384-48-0 CITROWANIL B
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: according to OECD 401, GLP lack of data on the purity / quality of the sample tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- The substance Citrowanil B M 2/585 Nr. 4 was a clear fluid in a brown glassbottle.
- IUPAC Name:
- The substance Citrowanil B M 2/585 Nr. 4 was a clear fluid in a brown glassbottle.
- Details on test material:
- Citrowanil B
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animals: SPF-Wistar-rats (strain Winkelmann, Paderborn) with mean body weights of 180 - 200 g.
The animals were kept in randomised groups kept in single cages.
They were fed with a laboratory standard diet by Altromin (Lage, Germany) and watered ad libitum.
Temperature: 22 +/- 1 °C
relative humidity: 45 - 55 %
daily illumination: 12 hours
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- Group IV: undiluted
- Details on oral exposure:
- Oral administration by non-flexible stomach tube after starving 16 hours.
- Doses:
- Group I: 1 ml/kg BW = 965.7 mg/kg BW
Group II: 2 ml/kg BW = 1931.4 mg/kg BW
Group III: 3 ml/kg BW = 2897.1 mg/kg BW
Group IV: 5 ml/kg BW = 4828.5 mg/kg BW - No. of animals per sex per dose:
- Group I and IV: 3
Group II and III: 5 - Control animals:
- no
- Statistics:
- Calculation of the LD 50 was made according to Lichfield & Wilcoxon
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2.2 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 - 2.5
- Remarks on result:
- other: Slope function S = 1.23 (1.13 - 1.34)
- Mortality:
- 48 hours 7 days 14 days
Group I: 0/6 0/6 0/6
Group II: 2/10 (1 male and 1 female) 4/10 (3 male and 1 female) 4/10 (3 male and 1 female)
Group III: 4/10 (2 male and 2 female) 8/10 (4 male and 4 female) 8/10 (4 male and 4 female)
Group IV: 4/6 (1 male and 3 female) 6/6 6/6 (Last 2 male animals died within 96 hours.)
The 48 hours LD50 was found at 3.6 ml of the product per kg of body weigt.
Since some late mortalities did occur, the 14 days-LD50 is 2.2 ml/kg of body weight. - Clinical signs:
- other: In all dosage groups the preparation caused 2 hours p.a. apathy, sedation, enforced respiration, abdominal ache, pinched eyes and diminished readines for reflexing. These symptoms continued up to 24 hours or caused mortalities. 4 out of 6 animals of the
- Gross pathology:
- Neither the acute mortalities nor the animals killed at the end of the test showed pathological changes in the cranium respectively in the thorax cavity. Intestinal in the acute mortalities slight hyperaemia was observed. These findings only did also occur in animals of final autopsy.
Any other information on results incl. tables
Development of Body Weights
Group | Sex | Starting Weight (g) | 14 Days Body Weight (g) |
I | male | 196.3 +/- 5.51 | 238.7 +/- 15.70 |
II | male | 197.0 +/- 4.53 | 220.5 +/- 19.50 |
III | male | 196.8 +/- 4.60 | 180.0 +/- - |
IV | male | 199.3 +/- 3.06 | - - |
I | female | 102.7 +/- 2.31 | 202.0 +/- 6.00 |
II | female | 193.2 +/- 2.59 | 193.3 +/- 11.00 |
III | female | 191.8 +/- 2.05 | 168.0 +/- - |
IV | female | 190.0 +/- 0.00 | - - |
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Considering the density of the test compound the LD 50 value is 2,024 mg/kg BW (> 2000 mg/kg BW, no classification) Criteria used for interpretation of results: OECD GHS
- Conclusions:
- This interpretation of results of the study does not confirm the classification according to Regulation (EC) No 1272/2008, Annex VI, Table 3.1 and 3.2.
- Executive summary:
The product Citrowanil B M 2/585 Nr. 4 was tested in an acute toxicity study after one oral application at the dosages of 1, 2, 3 and 5 ml /kg body weight to the rat with a 14 day observation period according to OECD 401.
The following results were found:
The 48 hours LD50 was found at 3.6 ml of the product per kg of body weigt. Since some late mortalities did occur, the 14 days-LD50 is 2.2 ml/kg of body weight.
Considering the density of the test compound the LD 50 value is 2,024 mg/kg BW.
The slope function was measurable well (1.23).
The toxic symptomatic was marked by quick occuring abdominal ache syndrome, increased frequently of respiration, apathy, sedation and diminished readiness for reflexing. After few hours these symptoms changen from sedation to coma.
The surviving animals of dosage groups showed a clear reduced development of body weight; with increasing dosage animals gained less weight.
Macroscopical adspection during autopsy did not show alterations in the cases of acute mortalities and also not at final autopsy in the cranium and thorax. Intestinal was observed hyperemic small and large intestines in acute mortalities and at final autopsy only.
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