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EC number: 485-350-6 | CAS number: 405095-33-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June - August 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- reliable with restrictions: GLP Guideline study according to OECD 301B; in deviation from the Guideline the volume of the test solution was reduced from 3.0l to 1.5l. The CO2 formed by biodegradation was absorbed with NaOH and determined on a carbon analyzer. The test was conducted without abiotic steril control and toxicity control. These restrictions are acceptable and do not impair the overall conclusion from the data.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- The volume of the test solution was reduced from 3.0l to 1.5l. The CO2 formed by biodegradation was absorbed with NaOH and determined on a carbon analyzer.
- GLP compliance:
- yes
- Remarks:
- This study has been performed in compliance with GLP in Switzerland, Procedures and Pronciples, March 1986, issued by the Swiss federal Department of the Interior and the Intercantonal Office for the Control of Medicaments.
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: bacteria collected from sewage treatment plant
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 11.1 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 8
- Sampling time:
- 28 d
- Remarks on result:
- other: test with 11.1 mg/L test substance
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 7
- Sampling time:
- 28 d
- Remarks on result:
- other: test with 20 mg/L test substance
- Details on results:
- Reference substance (Aniline MERCK No.: 1261) showed ready biodegradability.
- Validity criteria fulfilled:
- yes
- Remarks:
- criteria: aniline degradation (positive control) at day 28: 96 %; percentage degradation of positive control has reached pass level by day 14; difference between replicates < 20%; CO2 evolution in inoculum blanks does not exceed 40 mg/L
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- CA 1139 A is not biodegradable under the conditions of this test.
- Executive summary:
The ready biodegradabilty of CA 1139 A was determined in a 28 day CO2Evolution Test, according to GLP Guideline OECD 301B, under aerobic conditions in dark brown glass vessels at room temperature (22 ± 2 ºC). The experiment was conducted in compliance with Good Laboratory Pratice (GLP) in, Procedures and Principles, March 1986, issued by the Federal Department of the interior and the Intercantonal Office for the Control of Medicaments,.
The test substance was tested in concentrations of 11.1 and 20.0 mg/l test substance. The reference substance was tested at a concentration of 20.0 mg/l.
The test system consisted of bacteria collected from a sewage treatment plant. The preparation was carried out according to guideline.
The degradation was followed by analysis of CO2evolution at frequent intervals over a period of 28 days. Aniline served as positive control. The degree of biodegradation was calculated on the basis of the theoretical carbon content of the test substance and the cumulative quantities of CO2 determined on the days of measurements.
The mean value of the biodegradation of CA 1139 A after 28 days was 7.5 %. The Biodegradation of the reference substance after 28 days was 96 %.
On the basis of the present study CA 1139 A is not readily biodegradable.
Reference
Description of key information
The ready biodegradabilty of CA 1139 A was determined in a 28 day CO2Evolution Test,
according to GLP Guideline OECD 301B, under aerobic conditions in dark
brown glass vessels at room temperature (22 ± 2 ºC). The experiment was
conducted in compliance with Good Laboratory Pratice (GLP) in,
Procedures and Principles, March 1986, issued by the Federal Department
of the interior and the Intercantonal Office for the Control of
Medicaments,.
The test substance was tested in concentrations of 11.1 and 20.0 mg/l
test substance. The reference substance was tested at a concentration of
20.0 mg/l.
The test system consisted of bacteria collected from a sewage treatment
plant. The preparation was carried out according to guideline.
The degradation was followed by analysis of CO2evolution at frequent
intervals over a period of 28 days. Aniline served as positive control.
The degree of biodegradation was calculated on the basis of the
theoretical carbon content of the test substance and the cumulative
quantities of CO2 determined on the days of measurements.
The mean value of the biodegradation of CA 1139 A after 28 days was 7.5
%. The Biodegradation of the reference substance after 28 days was 96 %.
On the basis of the present study CA 1139 A is not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Guideline Test Type |
Species |
Ready Biodegradability |
Reference |
Reliability
|
OECD 301B |
bacteria collected from sewage treatment plant |
no |
Baumann, W., Ciba-Geigy, 1992 |
Reliable with restrictions |
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