Registration Dossier
Registration Dossier
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EC number: 413-210-6 | CAS number: 192662-33-2 ORASOL ROT 1988C
Endpoint summary
Administrative data
Description of key information
The substance did not cause mortality upon oral or dermal exposure of rats at the limit dose of 2000 mg/kg bw as tested in GLP compliant studies performed according to OECD testing guidelines 401 and 402, respectively (Ciba-Geigy 1992 a and b).
Key value for chemical safety assessment
Additional information
Upon an acute oral administration and a 14 day post-treatment observation period, the LD50 and LD0 of > 2000 mg/kg bw was determined for male and female rats (Ciba-Geigy 1992a). The study followed OECD testing guideline 401 and GLP.. Piloerection, hunched posture, and dyspnea were seen, being common symptoms in acute tests and the animals recovered within 4 to 6 days. No deviations from normal morphology were found in all animals at necropsy.
Upon an acute dermal administration and a 14 day post-treatment observation period, the LD50 and LD0 of > 2000 mg/kg bw was determined for male and female rats (Ciba-Geigy 1992b). The study followed OECD testing guideline 402 and GLP.. Piloerection was seen, being a common symptom in acute tests and the animals recovered within 2 days. No deviations from normal morphology were found in all animals at necropsy.
No experimental data is available regarding acute inhalation toxicity.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC):
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for acute oral or dermal toxicity under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008:
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for acute oral or dermal toxicity under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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