Registration Dossier
Registration Dossier
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EC number: 233-116-7 | CAS number: 10038-98-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: citation in Handbook
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The tox data is only a citation of the original publication (no reference detailed), therefore both studies were scored Klimisch 3, indicating that these values have limited value when they are used for risk assessment purposes.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Germanium. In Handbook on the Toxicology of Metals
- Author:
- Faroon, OM et al
- Year:
- 2 007
- Bibliographic source:
- Nordberg G.F. et al, Eds., 3rd ed. pp 557-567
Materials and methods
- Principles of method if other than guideline:
- No information. The tox data is only a citation of the original publication
- GLP compliance:
- not specified
- Test type:
- other: no information
- Limit test:
- no
Test material
- Reference substance name:
- Germanium dioxide
- EC Number:
- 215-180-8
- EC Name:
- Germanium dioxide
- Cas Number:
- 1310-53-8
- Molecular formula:
- GeO2
- IUPAC Name:
- Germanium dioxide
- Details on test material:
- none
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- none
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- none
- Doses:
- No information. The tox data is only a citation of the original publication
- No. of animals per sex per dose:
- No information. The tox data is only a citation of the original publication
- Control animals:
- not specified
- Details on study design:
- none
- Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 700 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50value of GeO2 was found to be above 2000 mg/kg bw in male rats indicating a low acute oral toxicity and no classification.
- Executive summary:
The acute oral toxicity of GeO2 is low. The LD50 for GeO2 in rats was 3700mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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