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Diss Factsheets
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EC number: 202-179-2 | CAS number: 92-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, pre-dates OECD guielines and some limitations in reporting but otherwise adequate for assessment.
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- Based on: Code of Federal Regulations, Title 16, Section 1500.42
- Deviations:
- no
- Remarks:
- 6 rabbit study
- GLP compliance:
- no
Test material
- Reference substance name:
- p-Phenylphenol
- IUPAC Name:
- p-Phenylphenol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Substance: p-Phenylphenol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: W. Ostrop / Meerbusch (Breeder)
- Weight at study initiation: average weight of 2.8 kg
- Housing: The animals were housed individually in cages
- Diet (e.g. ad libitum): provided with “Mümmel Z” feed (ssniff / Soest) ad libitum
- Water (e.g. ad libitum): water ad libitum
ENVIRONMENTAL CONDITIONS (Rearing conditions)
- Temperature (°C): 16 - 18
- Humidity (%): 40 (relative humidity)
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle
- Other:
- Male rabbits used
- Habituation period 7- 14 d.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The animal’s left eye remained untreated as a control.
- Amount / concentration applied:
- single application of 100 µl bulk volume
- Duration of treatment / exposure:
- 8 d (the eye was not rinsed after the application)
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Test execution: The test was performed on 6 pre-screened rabbits with an average weight of 2.8 kg by a single application of 100 µl bulk volume of the polymorphous substance in the conjunctival sack of each animal’s lower right eyelid. The lids were then gently held together for 1 sec. The eye was not rinsed after the application. The animal’s left eye remained untreated as a control.
The eyes were then examined with the aid of an ophthalmoscope.
The corneal result was verified after 8 d by the fluorescein test. (Instillation of one drop of fluorescein ophthalmic solution directly onto the cornea. After rinsing with physiological saline solution, corneal damage appears as a yellow-green area. UV light and cobalt blue filter)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.17
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
- Findings were recorded 24, 48 and 72 h and 8 days after the start of the test. The control findings after 8 d are not included in the appraisal for the irritation index.
- See the attached report for the results of mucous membrane irritation in rabbits.
- Primary irritation index: 12/18 = 0.7
- Classification: non-irritantApplicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The product is thus classified as a non irritant to the eye.
- Executive summary:
The aforementioned product yielded a primary irritation index of 0.7 in the primary mucous membrane irritation study conducted in accordance with Code of Federal Regulations, Title 16, Section 1500.42.
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