Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 482-400-9 | CAS number: 138776-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Qualifier:
- according to guideline
- Guideline:
- other: EEC C.4-D: Determination of ‘Ready Biodegradability (1998)
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA Harmonized Guideline 835.3110: Manometric Respirometry (1998)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 482-400-9
- EC Name:
- -
- Cas Number:
- 138776-88-2
- Molecular formula:
- C52H56O6P2
- IUPAC Name:
- 9-[(3,3',5,5'-tetra-tert-butyl-2'-{8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaen-9-yloxy}-[1,1'-biphenyl]-2-yl)oxy]-8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2,4,6,12,14-hexaene
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- ca. 40 mg/L
- Based on:
- test mat.
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 16.2
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 14.5
- St. dev.:
- 0.6
- Sampling time:
- 28 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 85.7
- St. dev.:
- 2.7
- Sampling time:
- 28 d
- Details on results:
- The amount of DOC in solution represented less than 50% of the theoretical dose as a result of its low water solubility.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The results of this study demonstrate that 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'- biphenyl]-2,2'-diyl] bis(oxy)]bis-dibenzo[d,f][1,3,2]-dioxaphosphepin did not meet either the pass level (> 60% DO2) or the 10-day window criteria for ready biodegradability in the Manometric Respirometry test. Degradation reached a maximum of 16.2% of THOD for the test material at the end of 28 days.
- Executive summary:
6,6'-[(3,3',5,5'-tetrakis (1,1 -dimethylethyl)-(1,1'-biphenyl]-2,2'-diyl] bis(oxy)] bis-dibenzo[d,f] {1,3,2 -}-dioxaphosphepin was evaluated for ready biodegradability according to the OECD Guideline 301F: Manometric Respirometry. Biodegradation was determined at an initial concentration of approximately 40mg/L, yielding approximately 100mg/L theoretical oxygen demand (ThOD) in the test mixtures. The test chemical was added to biodegradation test mixtures coated onto silica gel as a 15.9% load to facilitate contact with the solution. The biodegradation test mixtures were composed of a defined mineral medium, which was inoculated with activated sludge (30 mg/L dry solids) from a municipal wastewater treatment facility (Midland, MI, USA). Oxygen consumption and CO2 evolution resulting from biodegradation of the test chemicals were measured over 28 days using a Columbus Instruments Micro Oxymax® Respirometer System. In addition, removal of dissolved organic carbon (DOC) from these biodegradation test mixtures was determined after 28 days. The substance achieved 16.2% of ThOD and 14.5+ 0.6% ThCO2 after 28 days of incubation. While DOC removal achieved 85.7 + 2.7%, of test substance, the amount of DOC in solution represented less than 50% of the theoretical dose as a result of its low water solubility. As a result, the substance does not meet the criteria for ready biodegradability.
The suitability of the test procedure and microbial inoculum was verified by rapid biodegradation of aniline in the Positive Control test mixtures. Biodegradation of aniline based on O2 consumption exceeded 60% after an average of 7.8 days, reaching an average of 90.25% after 28 days. The toxicity control containing a combination of 100mg/L aniline and 100 mg equivalent ThOD the substance showed no inhibition of the microbial inoculum. The observed O2 consumption and CO2 evolution in the biodegradation reactions can be attributed solely to biological activity as no net O2 consumption or CO2 evolution was observed in the abiotic control reaction containing the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.