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Diss Factsheets
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EC number: 209-128-3 | CAS number: 556-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In the first study (Klein 1978), Leuciscus idus melanotus were exposed to Glycidol, 2,3-epoxipropanol. The following concentrations were used: Product solution 1 mL/L water; Dilution - 500 mL/L, 1:1; Dilution 250 mL/L, 1:4; and Dilution 125 mL/L, 1:8. The fish were exposed to the test material for a period of 48 hours in static conditions. Based on the results of this experiment, as the LC0 is greater than 100 mg/L, it is thought that the substance 2,3 -epoxypropanol (glycid) is not toxic to the aquatic environment.
In the second study (Anon. 1978) Leuciscus idus melanotus were exposed to Glycidol, 2,3-epoxipropanol for a period of 48 hours. The test animals didn’t show any toxic effects after an exposure period of 48 hours. This study was not considered to be reliable due to methodological deficiencies.
Two QSAR reports have been provided as supporting data for the short-term toxicity of 2,3 -epoxypropanol (glycid) to fish. ECOSAR and OECD (Q)SAR were used. The two QSAR models which were run used the following chemical input data:
Input Chemical Name: Oxiranemethanol
ECOSAR Class: mono epoxide and a neutral organic chemical
SMILES notation: O(C1CO)C1
Using ECOSAR, as the lethal toxicity of the epoxide chemical class is the worst case for this estimated value the fish LC50was determined to be 333.48 mg/L (Brady, 2010a).
Using OECD (Q)SAR Toolbox, as the lethal toxicity of the mono epoxide class was the worst case, the LC50was found to be 50.1 mg/L (Brady, 2010b).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 50.1 mg/L
Additional information
Based on the prediction results described above and as the substance is readily biodegradable, the substance 2,3-Epoxypropanol (Glycid) is not classified for toxicity to the aquatic environment according to Regulation (EC) No. 1272/2008 or Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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