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Diss Factsheets
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EC number: 231-658-9 | CAS number: 7680-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- No test guideline followed, inadequate documentation, no indication of purity. A method was used that has largely been superseded by metaphase analysis, and that is difficult to perform and read. No dose related effect is presented, and no historical control data are presented to see if the effect is within normal statistical bounds for controls.
Data source
Reference
- Reference Type:
- publication
- Title:
- Long-term effects of N-methylpyridinium chloride on the target organism
- Author:
- Antonenko T, Nechkina M, Nakoryakova M, Kulikova L & Chomutova T
- Year:
- 1 984
- Bibliographic source:
- Gigiena i Sanitariya (1984), 49(1), 74-75 (publication written in Russian)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- cytogenic analysis of spiral cord (anaphasic analysis, bone-marrow cells)
- GLP compliance:
- no
- Type of assay:
- unspecified
Test material
- Reference substance name:
- 1-methylpyridinium chloride
- EC Number:
- 231-658-9
- EC Name:
- 1-methylpyridinium chloride
- Cas Number:
- 7680-73-1
- Molecular formula:
- C6H8ClN
- IUPAC Name:
- 1-methylpyridin-1-ium chloride
- Details on test material:
- analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: white rats
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- rats were sacrified by breaking the cervical spine
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- no data
- Details on exposure:
- The substance was administered into the stomach.
- Frequency of treatment:
- a) single treatment at 1/50 LD50
b) repeated treatment at 1/500 LD50 and 1/5000 LD50 over a period of 45 days
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent no treatment
- Positive control(s):
- none
Examinations
- Tissues and cell types examined:
- cytogenic analysis of spiral cord (anaphasic analysis, bone-marrow cells)
Results and discussion
- Additional information on results:
- Cytogenic effects were reported. A single administration of 1/50 LD50 of the substance caused chromosome aberrations in the bone-marrow cells (primarily chromatid type). Repeated administration at 1/5000 LD50 showed chromosome and chromatid type aberrations.
Applicant's summary and conclusion
- Executive summary:
There was some evidence for potential clastogenic and mitotic effects in vivo. However the data are of limited reliability. Without any result from a proper guideline study no conclusion can be drawn.
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