Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 903-945-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- from 03 jan 1990 to 23 aug 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, OECD 401 compliant
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chlorodifluoroacetic acid
- EC Number:
- 200-928-8
- EC Name:
- Chlorodifluoroacetic acid
- Cas Number:
- 76-04-0
- Molecular formula:
- C2HClF2O2
- IUPAC Name:
- chloro(difluoro)acetic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa-Crédo (69592 L'Arbresle, France)
- Age at study initiation: 5 to 7 weeks old
- Weight at study initiation: 127 to 173 g
- Housing: 5 par sex and per group, in polycarbonte cages, type MI (365x225x180 mm)
- Diet (e.g. ad libitum): ad libitum, rat-mice pellets (U.A.R, formule A.04 - U.A.R Villemoison, 91360 Epinay/Orge, France)
- Water (e.g. ad libitum): softened and filtered water (0.6µm), ad libitum
- Acclimation period: 10 days before
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C
- Humidity (%): 30 to 70%
- Air changes (per hr): 10 minimum
- Photoperiod (hrs dark / hrs light): 12h/12h
IN-LIFE DATES: not indicated
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 0.066 mL/kg
- Doses:
- 0, 26, 56, 75 and 101 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing: the day before treatment, just before administration, Day 8 and Day 15, or just after death.
Clinical signs and mortality: 1/4 hour, 1 hour, 2 hours and 4 hours after gavage, then daily up to day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Clinical signs: breathing, piloerection, central nervous system, tremor, salivation . . .
In a preliminary test, the product was tested at the following doses: 62.7, 125.5, 250.9 and 500.3 mg/kg. There was 100% of mortality at 125.5, 250.9 and 500.3 mg/kg and 75% at 62.7 mg/kg.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 26 - < 56.6 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Lethality was caused by local corrosive effects.
- Mortality:
- 10% at 26 mg/kg, 80% at 56.6 mg/kg, 90% at 75 mg/kg and 100% at 101 mg/kg.
- Clinical signs:
- other: At 26 mg/kg: no clinical signs observed. At 56.6 mg/kg: roaring breathing, piloerection, ataxia. Nomore clinical signs after 7 or 8 days in the survivals. there 3/5 deaths in males and 5/5 deaths in females. At 75 mg/kg: ataxia in all animals, with roarin
- Gross pathology:
- Oesophagus perforation, stomach ulcer (at the highest dose), congestive areas in lungs.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Conclusions:
- Chlorodifluoroacetic acid is fatal if swallowed according to CLP 1272/2008.
- Executive summary:
In a GLP study, Chlorodifluoroacetic acid was tested to evaluate the acute toxicity following a single oral adminitration at doses from 0, 26, 56.6, 75 and 101 mg/kg bw undiluted.
There were 0, 10 80, 90 and 100% of mortality respectivley so the LD50 by oral route is between 26 and 56.1 mg/kg bw.
Macroscopic examination observation showed that mortality is related to strong corrosivity of CDFA and thus to local effects instead of actual systemic effects.
In these conditions, Chlorodifluoroacetic acid is considered fatal by ingestion according to CLP 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.