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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31th August to 26th September, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed following the OECD guideline, with GLP compliance. Deviations observed have no impact on the quality of the report and the study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- see below
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- yes
- Remarks:
- see below
- Principles of method if other than guideline:
- The pH in the test solution was not in the range 6-9 which is recommended in the guideline. Because the low pH in the highest concentrated treatment was caused by the acidic character of the test item and toxicity was not caused by the low pH, an additional experiment with pH adjustment was not performed.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:
- Sampling method: The concentrations were measured after 48h.
- Sample storage conditions before analysis: Temperature storage without details (Filtration over Nylon syringe filters is possible) - Vehicle:
- no
- Details on test solutions:
- A stock solution containing 250 ± 1 mg/L test item in dilution water will be prepared. The solutions of the amount needed will be prepared by dilution of this stock solution with dilu-tion water.
Following concentrations are tested: Control - 50 - 100 - 150 - 200 and 250 mg/L. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna (female)
- Variety: STRAUSS
- Strain: Berlin
- Source: Umweltbundesamt Berlin
- Age at study initiation: between 0 and 24 hours
- Weight at study initiation: no data
- Food type: unicellular green algae (Desmodesmus subspicatus)
- Amount: no data
- Frequency: at the beginning of the study - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No
- Hardness:
- No data
- Test temperature:
- The following temperature are observed:
- 22.5°C at 0h
- 21.6°C at 24h
- 21.3°C at 48h
Remarks on the deviation: The temperature for the main study lay in a range of 21.3 to 22.5 °C and therefore slightly higher than stated in the study plan. As no immobility was observed in the controls, this deviation was stated as uncritical. - pH:
- The pH values in the test media and the control ranged from 5.6 to 7.8.
- Dissolved oxygen:
- The concentration of dissolved oxygen stayed above 8.1 mg/L.
- Salinity:
- No data
- Nominal and measured concentrations:
- Nominal Concentration in mg/L
- 50
- 100
- 150
- 200
- 250
Measured Concentration in mg/L (at 0h):
- 48.86
- 100.36
- 151.04
- 203.06
- 251.57
Measured Concentration in mg/L (at 48h):
- 53.17
- 105.36
- 164.69
- 222.87
- 282.23
% Recovery after 48 h
- 108.81
- 104.98
- 109.03
- 109.75
- 112.19
% of Nominal Concentration (at 0h):
- 97.72
- 100.36
- 100.70
- 101.53
- 100.63
% of Nominal Concentration (at 48h):
- 106.33
- 105.36
- 109.79
- 111.43
- 112.89 - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Not determinable
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Not determinable
- Results with reference substance (positive control):
- The 24h-EC50 of potassium dichromate was determined as 1.5 mg/L, lying within the demanded range of 0.6 – 1.7 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50-48h (immobilization) for Reaction mass of N-[2-(2- Oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid = 180 mg/L. The study satisfy on the OECD guideline requirement and is GLP compliant.
- Executive summary:
The 48 hours acute toxicity of Reaction mass of N-[2-(2- Oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid to Daphnia magna was studied under static conditions. Daphnids were exposed to control and test chemical at measured concentration from 50 to 250 mg/L (test mat.) for 48 hours. Immobilization was observed daily. The 48 hours EC50was 180 mg/L (test material).
Based on the results of this study, Reaction mass of N-[2-(2- Oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid was not considered as dangerous for Daphnia magna in accordance with the EC classification criteria.
This study is rated as reliable without restriction and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrate (deviations observed have no impact on the quality of the results of this study).
Reference
Description of key information
EC50-48h (immobilization) for Reaction mass of N-[2-(2- Oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid = 180 mg/L. The study is based on the OECD guideline (202) requirement and is GLP compliant.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 180 mg/L
Additional information
The 48 hours acute toxicity of Reaction mass of N-[2-(2- Oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid to Daphnia magna was studied under static conditions. Daphnids were exposed to control and test chemical at measured concentrations from 50 to 250 mg/L (test mat.) for 48 hours. Immobilization was observed daily. The 48 hours EC50was 180 mg/L ( test material).
Based on the results of this study, Reaction mass of N-[2-(2- Oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid was not considered as dangerous for Daphnia magna in accordance with the EC classification criteria.
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