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EC number: 287-836-1 | CAS number: 85586-34-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A theoretical assessment of toxicokinetic behaviour is presented
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Soybean oil, epoxidised, ether with ethylene glycol is a UVCB substance. Based on its structure and physicochemical properties, it is considered related to epoxidised soybean oil which is also derived by epoxidation of soya bean oil.
No experimental data are available for either substance. OECD QSAR Toolbox (v3.1) predicts no oral bioavailability (Lipinski’s Rules; OASIS) for both substances, consistent with the high molecular weight and large molecular weight. A lack of dermal absorption is also predicted. Inhalation exposure is not relevant based on the physicochemical properties of the substances.
In its evaluation of epoxidised oils and derivatives, the OECD SIDS conclusion indicates that epoxidised fatty acid esters can be assumed to follow similar metabolic pathways to those of other vegetable oils since the primary constituents of the metabolic products are similar.
Based on structural, functional and metabolic similarities, primary epoxidised oils can be considered within one functional category. While the intact substances are not predicted to be absorbed, the 2006 OECD SIDS for Epoxidised Oils and Derivatives notes that epoxidised soybean oil is likely to be subject to degradation by intestinal lipase enzymes. This will therefore result in the liberation of epoxidised fatty acids and glycerol. Similar enzymic activity with the consequent liberation of fatty acid ethylene glycol esters is predicted for the submission substance. I t is therefore concluded that, although absorption of the intact substances is unlikely, oral administration to experimental animals may result in systemic exposure to the products of enzymic digestion. One potential difference between the substances is the possible liberation of small amounts of ethylene glycol from resulting from hydrolysis of the ether group present in the submission substance. However this is not considered likely to significantly influence the toxicity of the reference substance and, in any case, is only relevant to the oral route of exposure. Following metabolism, the alcohol metabolites are a minor constituent of metabolism and are not produced in sufficient quantity to influence the toxicity profile.
Absorption
The intact substance is not predicted to be absorbed by any route of exposure; however the action of lipase enzymes is likely to result in the liberation of epoxidised fatty acids (linked to ethylene glycol) and glycerol, which are likely to be systemically absorbed.
Distribution
Consideration of distribution following dermal and inhalation exposure is not relevant in the absence of predicted absorption. Following oral exposure, the products of enzymic hydrolysis will be distributed systemically, at least as far as the liver prior to further metabolism.
Metabolism
The hydrolysis product glycerol is likely to be incorporated into normal fat metabolism in the liver or adipose tissues. The ether linkage may be subject to enzymic hydrolysis, resulting in the liberation of ethylene glycol and esterified fatty acids. The metabolism of ethylene glycol is well chcracterised. Liberated esterified fatty acids may be incorporated into normal metabolism.
Excretion
Bearing in mind the likely metabolism of the substance, it is likely that the majority of its hydrolysis or metabolic products will be incorporated into normal metabolism and not excreted. The metabolites of ethylene glycol are likely to be subject to urinary excretion.
OECD SIDS (2006), Epoxidized Oils and Derivatives CAS No: 61789-01-3: Fatty acids, tall-oil, epoxidized, 2-ethylhexyl esters (ETP) 68609-92-7: 9-Octadecanoic acid (Z)-, epoxidized, ester W/propylene glycol (EODA) 8013-07-8: Epoxidized soybean oil (ESBO) 8016-11-3: Epoxidized linseed oil (ELSO or ELO), UNEP Publications
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