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EC number: 233-036-2 | CAS number: 10025-67-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 16-1 to 28-2-1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable deviations (LD50 expressed in µl/kg bw . Analytical purity was not reported. No acclimatisation period. Individual weights were not reported)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- LD50 expressed in µl/kg bw . Analytical purity was not reported. No acclimatisation period. Individual weights were not reported.
- GLP compliance:
- no
- Remarks:
- Study was conducted before GLP was mandatory
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disulphur dichloride
- EC Number:
- 233-036-2
- EC Name:
- Disulphur dichloride
- Cas Number:
- 10025-67-9
- Molecular formula:
- Cl2S2
- IUPAC Name:
- dichlorodisulfane
- Details on test material:
- - Name of test material (as cited in study report): disulphur dichloride
- Analytical purity: no data
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: 9 weeks (males), 14 weeks (females)
- Weight at study initiation: male rats weighed 166 g and female rats weighed 169 g at the beginning of the study
- Fasting period before study: rats were fastened 16 hrs before and 4 hrs after application of test substance
- Housing: Macrolon cage type III
- Diet (e.g. ad libitum): Altromin R1324 (Altromin GmbH, Lage, Germany) ad libitum (except during the fasting period).
- Water (e.g. ad libitum): tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22± 1.5 °C
- Humidity (%): 60± 5%
- Photoperiod (hrs dark / hrs light): 12hrs dark/ 12 hrs light
IN-LIFE DATES: From: 16-1-1984 To: 28-2-1984
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 50 , 60, 70, 80, 100 , 500 µl/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: On the day of the application the animals were monitored several times. On the following 14-day observation period the animals were examinated for mortality and clinical signs. The description, the onset, the duration and the intesity of the clinical symptome were recorded and the dead animals eliminated.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, grosspathology. - Statistics:
- The calculation of the LD50 with confidence limits for p less than 0.05, was determined according to Rosiello et al., 1977, J. Tox Environ Health 3, 797.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 132 mg/kg bw
- 95% CL:
- >= 69.7 - <= 89.4
- Remarks on result:
- other: Slope=3.28
- Clinical signs:
- other: Rats which died during assay or sacrificed after the assay showed the following signs: poor general condition, scrubby fur, prone/lateral position, narcosis, growth delay.
- Gross pathology:
- Rats which died during assay or sacrificed after the assay showed the following signs: after high doses changes of the stomach mucosa and corrosion. Liver and spleen were partial black-brown coloured.
Any other information on results incl. tables
Intensity , appearance of symptoms and death are described
as follows:
group dose number time of death
[µl/ml] [m/f/total]
1 50 0/0/10 -
2 60 2/10/10 4 -8 days
3 70 4/10/10 3 -6 days
4 80 6/10/10 8 hours - 7 days
5 100 7/10/10 30 min - 6 days
6 500 10/10/10 30 min - 8 days
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Executive summary:
Loeser (Bayer AG), 1984
Acute oral toxicological examinations were conducted with disulphur dichloride on male and female Wistar rats, according to OECD guideline 401 with deviations (LD50 expressed in µL/ kg bw instead of mg/kg bw. Analytical purity was not reported. Animals were not subjected to acclimation period. Indivual weights were recorded just at the beginning and at the end of the application.Changes in weight were not reported).Six different single oral doses of the test substance (50, 60, 70, 80, 100 and 500 µl/kg bw) were administered via gavage to 5 male and 5 female rats. The post-exposure observation period was 14 days.
The calculated LD50 resulted to be 78 µL/kg body weight (132 mg/kg bw; slope = 3.28), for male and female rats.
The following poisoning symptoms were observed: poor general condition, scrubby fur, prone position/lateral position, narcosis, delay in growth.On the basis of the results of this test, disulphur dichloride can be classified as:
EU: T, R25: Toxic if swallowed
OECD GHS: Acute oral toxicity-Category 3.Warning H301, Toxic if swallowed.
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