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EC number: 287-842-4 | CAS number: 85586-40-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Substance is practically non-toxic
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 June to 23 August 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Internal Guideline Hoechst AG
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG - own breeding
- Age at study initiation: ca. 6 weeks
- Weight at study initiation: 80 to 127 g (females)
- Fasting period before study: 16 hours before to 2 hours after dosing
- Housing: in groups
- Diet: Altromin 1324 ad libitum
- Water: tap ad libitum
- Acclimation period: NA
IN-LIFE DATES: From: 30 June to 23 August 1976 - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% (250 mg/mL)
- Amount of vehicle (if gavage): 20 mL/kg - Doses:
- 6300, 8000, 10000, and 15000 mg/kg bw
- No. of animals per sex per dose:
- 10 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation: clinical signs multiple times on day one, thereafter twice daily; body weight: weekly
- Necropsy of survivors performed: yes - Statistics:
- Die LD 50 wurde mittels einer Probitanalyse (Methode nach LINDER und WEBER) bestimmt; die Vertrauensgrenzen wurden nach CAVALLI-SFORZA berechnet (Abt. f. Prakt. Mathematik der Hoechst Aktiengesellschaft) .
- Preliminary study:
- NA
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 9 246 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 8 306 - 10 293
- Remarks on result:
- other: no gender-related differences were noted in preliminary tests
- Mortality:
- No animals died at 6300 mg/kg
3, 6, and 10 rats died at 8000, 10000, and 15000 mg/kg, respectively - Clinical signs:
- other: no clinical signs in surviving rats. Dying rats showed diarrhea, tonic-clonic convulsions and prone position prior to death.
- Gross pathology:
- At necropsy of deceased rats, all inner abdominal organs were red discoloured.
Necropsy of terminal rats revealed a slightly violet discolouration of skin, subcutis and cartilages. - Other findings:
- Urine and feces were reddish discolored in all animals.
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral medial lethal dose was calculated by Probit analysis to be 9246 mg/kg bw in female Hoe:WISKf(SPF71) rats
- Executive summary:
The test substance was tested for acute oral toxicity in 10 female Wistar rats per dose group. The test substance was administered as a single dose of 6300, 8000, 10000, and 15000 mg/kg bw by gavage after a 16-hour fasting period. The animals were observed for 14 days for signs of toxicity and body weight development.
Died rats, or surviving rats at the end of the observation period underwent necropsy and macroscopical evaluation. Dying rats showed diarrhea, tonic-clonic convulsions and prone position prior to death. Urine and faeces were reddish discoloured in all animals. At necropsy of deceased rats, all inner abdominal organs were red discoloured. Necropsy of terminal rats revealed a slightly violet discolouration of skin, subcutis and cartilages. No animals died at 6300 mg/kg, 3, 6, and 10 rats died at 8000, 10000, and 15000 mg/kg, respectively. The LD50 was calculated by Probit analysis to be 9246 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 9 246 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The test substance was tested for acute oral toxicity in 10 female Wistar rats per dose group. The test substance was administered as a single dose of 6300, 8000, 10000, and 15000 mg/kg bw by gavage after a 16-hour fasting period. The animals were observed for 14 days for signs of toxicity and body weight development.
Died rats, or surviving rats at the end of the observation period underwent necropsy and macroscopical evaluation. Dying rats showed diarrhea, tonic-clonic convulsions and prone position prior to death. Urine and faeceswere reddish discoloured in all animals. At necropsy of deceased rats, all inner abdominal organs were red discoloured. Necropsy of terminal rats revealed a slightly violet discolouration of skin, subcutis and cartilages. No animals died at 6300 mg/kg; 3, 6, and 10 rats died at 8000, 10000, and 15000 mg/kg, respectively. The LD50 was calculated by Probit analysis to be 9246 mg/kg bw.Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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