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EC number: 291-378-8 | CAS number: 90388-00-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Heptadecanol, branched and linear
- EC Number:
- 291-378-8
- EC Name:
- Heptadecanol, branched and linear
- Cas Number:
- 90388-00-4
- Molecular formula:
- C17H36O
- IUPAC Name:
- 2-methylhexadecan-1-ol; heptadecan-1-ol
- Details on test material:
- Name of the test substance used in the study report: HEPTADECANOL N
Purity: 99.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Age when treated: 11 weeks
Body weight when treated: 180 - 189 g
The rats were identified using unique cage number and corresponding color-coded spots on the tail.
The animals were housed in air-conditioned rooms with a room temperature of 22 +/°C and a relative humdity between 30 - 70%. The day/night rhythm was 12 h light and 12 h dark.
Three animals per cage (type Makrolon 4 with wire mesh tops and standard softwood bedding).
The rats were offered a standardized laboratory diet as well as tap water ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE:
Yellowish oily liquid
Batch Number: 24788186
Source: Carl Roth GmbH & Co., 76185 Karlsruhe / Germany
Stability: Stable under storage conditions
Expiry Date: 30-Nov-2012
Storage Conditions: At room temperature (range of 20 ± 3°C), light protected.
Safety Precautions: Routine hygienic procedures were used to ensure the health and safety of the personnel.
Olive oil was found to be a suitable vehicle.
TEST ITEM:
Dosing volume: 10 m l/kg b.w. - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 6 (2 test groups)
- Control animals:
- no
- Details on study design:
- Clinical signs: Daily during the acclimatization period, during the first 30 min and approx. 1, 2, 3 and 5 h after administration on test day 1, depending on the occurrence of clinical signs of toxciity. Once daily during days 2 - 15.
Body weight: On tst day 1 (prior to administration), 8 and 15.
Viability/Mortality: Daily during the acclimatization period, during the first 30 min and at approx. 1, 2, 3 and 5 h after administration on test day 1 (in common with the clinical signs) and twice daily during days 2 - 15.
Necropsy: All animals were killed at the end of the observation period by carbon dioxide asphyxiation and discarded after macroscopic examinations were performed. No organs or tissues were retained.
Observation period: 15 days
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no deaths
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.