Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-266-7 | CAS number: 4747-21-1
Endpoint summary
Administrative data
Description of key information
The corrosive potential of N-Methylisopropylamine (MIPA) was assessed in the in vitro Human epidermis model EpiDerm™, according to the OECD TG 431 (BASFSE61H0834/072202, 2002). N-Methylisopropylamine showed a corrosive potential under the test conditions chosen.
No study on the eye is available; nevertheless, since MIPA was shown to be corrosive, no testing for eye irritation is needed according to column 2 of REACH Annex VII.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Additional information
The corrosive potential of N-Methylisopropylamine was assessed in the in vitro Human epidermis model EpiDerm™, according to the OECD TG 431 (2004). The EpiDerm™ tissue samples were incubated with the test item for 3 minutes and 1 hour, each. Tissue destruction was determined by measuring the metabolic activity of the tissue after exposure using a colorimetric test. The reduction of mitochondrial dehydrogenase activity, measured by reduced formazan production after incubation with a tetrazolium salt (MTT) was chosen as suitable endpoint. The formazan production of the test-substance treated epidermal tissues was compared to that of negative control tissues by measuring the optical density (OD) at a wavelength of 570 nm. The quotient of both values indicates the relative tissue viability(BASFSE61H0834/072202, 2002)
After 3 minutes of exposure, cell viability for the test item-treated tissues was 10% of control. After 1 hour of exposure, cell viability for the test item- treated tissues was 7% of control. It was concluded, that N-Methylisopropylamine shows a corrosive potential in the EpiDerm™ skin corrosivity test under the test conditions chosen.
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
N-Methylisopropylamine showed a corrosive potential in the EpiDerm™ skin corrosivity test, Therefore classification as Corrosive R35 is warranted according to the EU Directive 67/548/EC, and classification in Cat 1A is warranted according to the CLP Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
