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Diss Factsheets
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EC number: 288-922-1 | CAS number: 85940-32-5 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Elettaria cardamomum, Zingiberaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- Classification based on calculation rules for mixtures of the CLP Regulation
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Reference
- Reference Type:
- other: Guidance
- Title:
- Guidance on the Application of the CLP Criteria - Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
- Author:
- ECHA
- Year:
- 2 017
- Bibliographic source:
- ECHA-17-G-21-EN
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Classification based on calculation rules for mixtures of the CLP Regulation
Test material
- Reference substance name:
- Cardamom, ext.
- EC Number:
- 288-922-1
- EC Name:
- Cardamom, ext.
- Cas Number:
- 85940-32-5
- Molecular formula:
- Not applicable, UVCB
- IUPAC Name:
- 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane; 2-(4-methylcyclohex-3-en-1-yl)propan-2-yl acetate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Cardamom oil
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: classification
- Remarks on result:
- other: skin irritant category 2
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The registered substance has more than 10% of its constituents classified as Skin irritant Category 2 and should be classified as a skin irritant without further testing according to the rules for classification of mixtures of Regulation (EC) No 1272/2008.
- Executive summary:
The NCS is composed of several identified constituents and in that, it can be considered as a mixture according to the definition of the CLP Regulation.
The decision logic for classification of mixtures from the ECHA Guidance on the Application of the CLP Criteria (2017) was used to determine the skin irritation/corrosion hazard of the registered substance. The decision of classification as skin irritant was based on existing data on constituents (additivity principles): the registered substance has more than 10% of its constituents classified as Skin irritant Category 2 and should be classified as a skin irritant without further testing according to the rules for classification of mixtures of Regulation (EC) No 1272/2008.
Constituent CAS Classification Source Linalyl acetate 115-95-7 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/14484 Limonene 138-86-3 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/24067 Linalool 78-70-6 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/14501/1 Beta-myrcene 123-35-3 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/14795 Terpineol multiconstituent 8000-41-7 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/16031/2/1 Geranyl acetate 105-87-3 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/5962 Terpineol-4 562-74-3 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/21354 Alpha pinene 80-56-8 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/14724 Geraniol 106-24-1 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/14184 Geranial 141-27-5 H315 ECHA C&L inventory - self classification: https://echa.europa.eu/fr/registration-dossier/-/registered-dossier/17552 Source: ECHA disseminated dossiers or self classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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