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EC number: 617-976-4 | CAS number: 871544-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 January 2005 - 2 February 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- lithium(1+) [2-methoxy-4-(trifluoromethyl)pyridin-3-yl]sulfanide
- EC Number:
- 617-976-4
- Cas Number:
- 871544-06-8
- Molecular formula:
- C7H5NOF3S.Li
- IUPAC Name:
- lithium(1+) [2-methoxy-4-(trifluoromethyl)pyridin-3-yl]sulfanide
- Details on test material:
- 3-Pyridinethiol, 2-methoxy-4-(trifluoromethyl)-lithium salt
Appearance: dark brown aqueous solution
Storage: room temperature
pH: 11 - 12 (by wetted pH paper)
Solubility: soluble in water, methanol, ethanol, and acetone. Mineral oil: 3-Pyridinethiol, 2-methoxy-4-(trifluoromethyl)-lithium salt soluble, aqueous solution not soluble.
Stability: test substance was expected to be stable for the duration of testing
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Raleigh, NC
- Age at study initiation: 9 weeks
- Weight at study initiation: Males 194 - 203 g; Females 128 - 140 g
- Housing: The animals were individually housed in suspended stainless steel caging with mesh floors. Litter paper was placed beneath the cage and was changed at least three times per week.
- Diet (e.g. ad libitum): Certified Rodent Diet (PMI #5002)
- Water (e.g. ad libitum): Filtered tap water was supplied ad libitum by an automatic water dispensing system.
Contaminants: There were no known contaminants reasonably expected to be found in the food or water at levels which would have interfered with the results of this study. Analysis of the water is conducted at least once a year and the records are kept on file at Product Safety Laboratories. The most recent analysis was conducted in December 2004. Purina Certified Rodent Diet, PMI #5002, Lot Number: NOV 23 04 3A, was analyzed in December 2004.
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 23°C
- Humidity (%): 30-55% relative
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The sample was applied as received. Five thousand mg/kg of body weight of the test substance was applied evenly over a shaved dose area of approximately 2 inches x 3 inches (approximately 10% of the body surface) and covered with a 2-inch x 3-inch, 4-ply gauze pad. The gauze pad and entire trunk of each animal were then wrapped with 3-inch Durapore tape to avoid dislocation of the pad and to minimize loss of the test substance.
After 24 hours of exposure to the test substance, the pads were removed and the test sites were gently cleansed of any residual test substance. - Duration of exposure:
- 24 hours, followed by a 14 day observation period.
- Doses:
- 5000 mg/kg/bw
- No. of animals per sex per dose:
- 5 male
5 female - Control animals:
- no
- Details on study design:
- -Preparation and Selection of Animals
On the day prior to application, a group of animals was prepared by clipping (Oster model #A5-small) the dorsal area and the trunk. After clipping and prior to application, the animals were examined for health, weighed (initial) and the skin checked for any abnormalities. Ten healthy rats were selected.
-Dose Calculations
Individual doses were calculated based on the initial body weights, taking into account the specific gravity (determined by PSL) of the test substance.
-Application of Test Substance
After the application, rats were returned to their designated cages. The day of application was considered Day 0 of the study.
After 24 hours of exposure to the test substance, the pads were removed and the test sites were gently cleansed of any residual test substance.
-Body Weights
Individual body weights of the animals were recorded prior to test substance application (initial) and again on Days 7 and 14 (termination).
-Cage-Side Observations
The animals were observed for mortality, signs of gross toxicity, and behavioural changes during the first several hours after application and at least once daily thereafter for 14 days. Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity and behaviour pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhoea, and coma.
-Necropsy
All rats were euthanized via CO2 inhalation on Day 14. Gross necropsies were performed on all animals. The external surface of the body and all orifices, tissues, and organs of the thoracic and abdominal cavities were examined.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: There were no mortalities, signs of gross toxicity, dermal irritation, adverse clinical signs, or abnormal behaviour.
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: All animals appeared active and healthy during the study. There were no signs of gross toxicity, dermal irritation, adverse clinical signs, or abnormal behaviour. A brown stain was observed on the dose site.
- Gross pathology:
- No gross abnormalities were noted for the animals when necropsied at the conclusion of the 14-day observation period.
Any other information on results incl. tables
Individual Body Weight and Doses:
Animal No. |
Sex |
Body weight (g) |
Dose* |
||
Initial |
Day 7 |
Day 14 |
mL |
||
9943 |
M |
203 |
233 |
259 |
0.93 |
9944 |
M |
199 |
228 |
256 |
0.91 |
9945 |
M |
194 |
219 |
250 |
0.89 |
9946 |
M |
197 |
224 |
261 |
0.90 |
9947 |
M |
200 |
233 |
266 |
0.92 |
9948 |
F |
140 |
151 |
170 |
0.64 |
9949 |
F |
132 |
139 |
164 |
0.61 |
9950 |
F |
128 |
136 |
169 |
0.59 |
9951 |
F |
133 |
144 |
173 |
0.61 |
9952 |
F |
140 |
147 |
172 |
0.64 |
*Specific gravity 1.090 g/mL
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the acute dermal LD50 of the test substance was determined to be greater than 5,000 mg/kg of body weight in male and female rats.
- Executive summary:
Under the conditions of this study, the acute dermal LD50 of the test substance was determined to be greater than 5,000 mg/kg of body weight in male and female rats. The study was conducted in accordance with U.S. EPA Health Effects Test Guidelines, OPPTS 870.1200 (1998).
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