N-[3-(dimethylamino)propyl]methacrylamide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Range-finding study.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Guideline:

other: Range-finding test

Principles of method if other than guideline:

Range finding test
6 female Harlan-Wistar Albino rats were dynamically exposed to substantially saturated vapor of Dimethylaminopropyl Methacrylamide at 23.5 °C for 8 hours.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

N-[3-(dimethylamino)propyl]methacrylamide

EC Number:

226-002-3

EC Name:

N-[3-(dimethylamino)propyl]methacrylamide

Cas Number:

5205-93-6

Molecular formula:

C9H18N2O

IUPAC Name:

N-[3-(dimethylamino)propyl]-2-methylacrylamide

Test material form:

liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Dimethylaminopropyl Methacrylamide
- Molecular weight (if other than submission substance): 170.25 g/mol

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: ca. 100.6 gram.
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23.5 °C
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: no data
- Exposure chamber volume: no data
- Method of holding animals in test chamber: no data
- Source and rate of air: no data
- Method of conditioning air: no data
- System of generating particulates/aerosols: no data
- Method of particle size determination: no data
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data


TEST ATMOSPHERE
- Brief description of analytical method used: no data
- Samples taken from breathing zone: no

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Remarks on duration:

at 23.5 °C

Concentrations:

saturated vapour

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LCLo

Effect level:

other: dynamic exposure, saturated vapour at 23.5 °C

Exp. duration:

8 h

Remarks on result:

other: Died: 0/6, Signs of intoxication: None, Gross autopsy: Nothing remarkable

Mortality:

Dosage: Saturated vapour: Died: 0/6 female animals

Clinical signs:

other: None

Body weight:

Dosage mean body weight (g)
I T
saturated vapour 100.6 171.0

Gross pathology:

Nothing remarkable.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

During the experiment 0/ 6 animals died therefore Dimethylaminopropyl methacrylamide is considered to be of low Toxicity based on the results on
female rats. No toxicity in a saturated atmosphere (23.5 °C, 8 hours).

Executive summary:

In an acute inhalation toxicity study (Range-finding test), 6 female Harlan-Wistar Albino rats (source: no data, age: no data, weight: ca. 100.6 gram), were dynamically exposed to substantially saturated vapour of Dimethylaminopropyl methacrylamide (purity: >=98%) for 8 hours at 23.5 °C.  Animals were then observed for 14 days.

 

Result: 0/ 6 animals died therefore Dimethylaminopropyl methacrylamide is of low toxicity based on the results on female rats.