Registration Dossier
Registration Dossier
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EC number: 225-969-9 | CAS number: 5188-07-8
Endpoint summary
Administrative data
Description of key information
Sodium methylmercaptide is corrosive to the skin of the rabbit after a three-minute exposure period and assumed to be a serious eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Additional information
Skin irritation
A primary skin irritation study using New Zealand White rabbits was performed with a 21% solution of sodium methanethiolate in water according to the OECD Test Guideline 404 (Douds, 1977). Six rabbits received a 0.5 ml dose of the solution as a single dermal application under semi-occlusive conditions for 3 minutes. At one hour, necrosis (grades 1-4) and blanching (grades 3-4) were observed at all 6 sites. At 24 hours post-dose, 5/6 test sites were observed with necrosis (grades 1-2) and 6/6 test sites were blanched (grades 2-4) and had eschar (grades 1-3). Sodium methanethiolate, in a 21% aqueous solution, was determined to be corrosive, causing severe burns, to rabbit skin following a 3-minute exposure.
Effects on skin irritation/corrosion: corrosive
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
According to REGULATION (EC) No 1272/2008:
- pure sodium methylmercaptide: corrosive to skin (category 1A) and causes serious eye damage (category 1)
According to DIRECTIVE 67/548/EEC
- pure sodium methylmercaptide: causes severe burns (R35)
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