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Diss Factsheets
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EC number: 210-959-9 | CAS number: 626-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (limited documentation).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted in 1981
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpiperidine
- EC Number:
- 210-959-9
- EC Name:
- 1-methylpiperidine
- Cas Number:
- 626-67-5
- Molecular formula:
- C6H13N
- IUPAC Name:
- 1-methylpiperidine
- Details on test material:
- - Name of test material (as cited in study report): Methylpiperidine
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: breeder, Gassner
- Weight at study initiation: males: 215 ± 21 g; females: 185 ± 13 g
ENVIRONMENTAL CONDITIONS
- No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: The doses were applied as 2 % , 4 %, 8 % or 20 % v/v preparations of the test substance in aqua dest.
- Justification for choice of vehicle: soluble in water
MAXIMUM DOSE VOLUME APPLIED: 12.5 mL/kg - Doses:
- 200, 400, 500, 640, 800 and 1600 µL/kg bw (corresponding to approx. 163, 327, 408, 523, 653 and 1306 mg/kg bw; calculation based on density of 0.8165 g/cm³)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 13 days
- Frequency of observations and weighing: Body weight was determined before the beginning of the study for dose calculation. Observation of clinical signs was determined several times on the day of administration and once daily afterwards with the exception of weekends and on holidays.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 490 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The original value 0.6 mL/kg was converted to mg/kg body weight using the density of 0.8165 g/cm³
- Mortality:
- Results are given as dead animals/total number of animals:
163 mg/kg bw: 0/10 males and 0/10 females
327 mg/kg bw: 0/10 males and 0/10 females
408 mg/kg bw: 0/10 males; 1/10 females within 24 hours
523 mg/kg bw: 3/10 males within 24 hours and 8/10 females within 24 hours and 9/10 females within 48 hours
653 mg/kg bw: 8/10 males and 10/10 females within 24 hours, respectively
1306 mg/kg bw: 10/10 males and 10/10 females within 24 hours - Clinical signs:
- other: 163 mg/kg bw: immediately after gavage sedate behaviour, accelerated respiration, convulsion; one day after treatment: sedate behaviour, accelerated respiration, scrubby fur; day 2 to 6 sedate behaviour and on day 7 scrubby fur. From day 8 nothing abnorma
- Gross pathology:
- Deceased animals:
once bloody erosion at the stomach; twice oedema at the stomach wall; no other abnormalities detected.
Sacrifized animals:
no abnormalities detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.