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EC number: 240-986-1 | CAS number: 16924-00-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 March 1992 to 13 April 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dipotassium heptafluorotantalate
- EC Number:
- 240-986-1
- EC Name:
- Dipotassium heptafluorotantalate
- Cas Number:
- 16924-00-8
- Molecular formula:
- F7Ta.2K
- IUPAC Name:
- Tantalate(2-), heptafluoro-, potassium (1:2)
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material : Di-Kaliumtantalfuorotantalate (Kaliumtantalflourid)
- Molecular formula: K2TaF7
- Physical state: White Crystals
- Storage condition of test material: Within a closed drum, protected against humidity.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Supplier Thomae Biberach
- Weight at study initiation: 2.97 kg ± 0.052
- Housing: Individually in steel wire cages
- Diet: Altromin K, Type 2023, pasteurised laboratory small animal diet, ad libitum.
- Water: ad libitum mains supply.
- Acclimation period: Minimum of 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature: 20ºC ± 2 ºC
- Humidity: 40 -60-%
- Air changes: 12-15 times/hour
- Photoperiod: 12 hrs light, 12 hours dark.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.2mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 0.5, 1, 4, 6, 24, 48, and 72 hours and day 6.
- Number of animals:
- 6 males
- Details on study design:
- TEST SITE
- Area of exposure: On the day prior to application hair was shaved from an area approximately 30 cm x 20 cm on the dorsal trunk. 0.5g of the test substance was placed on a 6 cm² gauze patch and moistened with 0.2ml of water. The patch was positioned on the right side of the dorsal midline.
- Type of wrap if used: 6cm² gauze was secured to the test area with Leukoplast.
REMOVAL OF TEST MATERIAL
- Washing: At the end of the exposure period the dressing was removed and gently washed away with water.
- Time after start of exposure: 4 hours
SCORING SYSTEM: The Draize scale (Draize 1959, presented as table 1 in the field "Any other information on materials and methods incl. tables") was used to asses the degree of erythema and oedema at the application sites 0.5, 1, 4, 6, 24, 48, and 72 hours and 6 days after the exposure period prior to necropsy.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 6 days
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Irritant / corrosive response data:
- Neither erythema or oedema were detected during the observation period according to the Draize scale.
- Other effects:
- A slight to barely perceptible whitish appearance was detected after patch removal, which was shed in the following days. Through microscopic findings this was interpreted as a slight dehydration of the surface layers of the skin. Results are presented in table 2 in the field " any other information on results incl. tables".
There were no other signs of ill-health in any animal during the study.
Any other information on results incl. tables
Table 2: Clinical Observations
Key:
N - normal behaviour
W - slightly whitish coloured skin (treated area)
(W) - barely perceptible whitish coloured skin (treated area)
Animal No., Sex | 1M | 2M | 3M | 4M | 5M | 6M |
day 0 | N | NW | N | N | N | N |
day 1 | N (W) | NW | N | N (W) | N | N |
day 2 | N | N (W) | N | N | N | N |
day 3 | N | N | N | N | N | N |
day 4 | N | N | N | N | N | N |
day 5 | N | N | N | N | N | N |
day 6 | N | N | N | N | N | N |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the test material did not evoke any reaction in any of the test animals. Therefore the test material does not require classification as a skin irritant.
- Executive summary:
The skin irritation of the test material was determined in accordance with the standardised guidelines EPA OPP 81-5 (Acute Dermal Irritation). Six rabbits received a single application of 0.5g of the test material for four hours and were assessed for the following 6 days for any sign of skin irritation. Neither erythema or oedema were seen in any of the tests animals over the observation period. Only a slight dehydration of the skin was observed in the test area which subsequently disappeared in the following days after patch removal. There were no other signs of skin irritation.
Under the conditions of the study, the test material is considered to be non-irritating to the skin.
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