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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well conducted GLP study according to OECD Guideline 121
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- yes
- Remarks:
- The test and reference substances were prepared and dissolved in methanol instead of the mobile phase, due to solubility issues of the test substance
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Details on study design: HPLC method:
- • Autosampler: Spark, model Midas
• Pump: Spark, model 1000 HPLC pump
• Column: Alltech, Platinum CN 100A 5µ 150mm without guard column
• Column temp.: 30 ºC
• Mobile Phase: Methanol : Water 40 : 60 (v/v)
• Flow rate: 0.7 mL/min
• Detector: Separations UV/VIS detector Smartline 2500
• Wavelength: 210 nm
• Software Dionex, Chromeleon version 7.2.2.6394 - Analytical monitoring:
- yes
- Details on sampling:
- The test substance as well as the reference substances were measured in duplicate. For the test substance and each reference substance a stock solution was prepared by weighing exact amounts of substance in 50 mL volumetric flasks. The volumetric flasks were filled up to the mark with methanol. Dilutions from these stock solutions were made in methanol and analyzed using the conditions described above. In table II the concentrations of the stock solutions from the test substance and reference substances are described, together with the final injection concentrations after dilution.
Table II: Stock solution concentrations test and reference substances and there injection concentration
Substance Stock concentration (mg/L) Injection concentration (mg/L)
Sodium nitrate (dead time) 1062 20
Acetanilide 194 10
Methylbenzoate 688 10
Aniline 1226 10
Naphthalene 704 10
1,2,3-trichlorobenzene 570 10
Phenantrene 432 10
Test substance 10144 5000 - Details on matrix:
- Test substance and reference substances were prepared and dissolved in methanol.
- Type:
- log Koc
- Value:
- 1.9
- Details on results (HPLC method):
- In the test, the adsorption coefficient (Koc) was deduced from the capacity factor (k) using a calibration plot of Log Koc versus Log k of the selected reference substances. The test substance was measured in duplicate and this resulted in an average Log Koc value of 1.9.
The retention times are depicted in a table in paragraph 'any other information on results incl. tables'
The details of fitted regression line (log k' vs. log Koc) are depicted in section 'Illustration (picture/graph)' - Conclusions:
- In the test, the adsorption coefficient (Koc) was deduced from the capacity factor (k) using a calibration plot of Log Koc versus Log k of the selected reference substances. The test substance was measured in duplicate and this resulted in an average Log Koc value of 1.9.
- Executive summary:
Well described GLP study, carried out according to OECD guideline.
Reference
Table: Average retention times of the reference substances and test substance
Substance |
Log Koc theoretical |
Average Retention time (min) |
Average Log k |
Sodium nitrate (dead time) |
|
1.630 |
|
Acetanilide |
1.25 |
2.988 |
-0.08 |
Methylbenzoate |
1.8 |
3.219 |
-0.01 |
Aniline |
2.07 |
3.051 |
-0.06 |
Naphthalene |
2.75 |
4.018 |
0.17 |
1,2,3-trichlorobenzene |
3.16 |
3.773 |
0.12 |
Phenantrene |
4.09 |
5.478 |
0.37 |
Test substance |
|
3.165 |
-0.03 |
Description of key information
The results of an OECD 121 study indicated that the log Koc is 1.9
Key value for chemical safety assessment
- Koc at 20 °C:
- 79.4
Additional information
In the test, the adsorption coefficient (Koc) was deduced from the capacity factor (k) using a calibration plot of Log Koc versus Log k of the selected reference substances. The test substance was measured in duplicate and this resulted in an average Log Koc value of 1.9.
[LogKoc: 1.9]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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